Epigenetic regulation of Fgf1 transcription by CRTC1 and memory enhancement

Recent evidence demonstrates that epigenetic regulation of gene transcription is critically involved in learning and memory. Here, we discuss the role of histone acetylation and DNA methylation, which are two best understood epigenetic processes in memory processes. More specifically, we focus on le...

Descripción completa

Detalles Bibliográficos
Autores principales: Uchida, Shusaku, Shumyatsky, Gleb P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128695/
https://www.ncbi.nlm.nih.gov/pubmed/29477835
http://dx.doi.org/10.1016/j.brainresbull.2018.02.016
_version_ 1783353690868940800
author Uchida, Shusaku
Shumyatsky, Gleb P.
author_facet Uchida, Shusaku
Shumyatsky, Gleb P.
author_sort Uchida, Shusaku
collection PubMed
description Recent evidence demonstrates that epigenetic regulation of gene transcription is critically involved in learning and memory. Here, we discuss the role of histone acetylation and DNA methylation, which are two best understood epigenetic processes in memory processes. More specifically, we focus on learning-strength-dependent changes in chromatin on the fibroblast growth factor 1 (Fgf1) gene and on the molecular events that modulate regulation of Fgf1 transcription, required for memory enhancement, with the specific focus on CREB-regulated transcription coactivator 1 (CRTC1).
format Online
Article
Text
id pubmed-6128695
institution National Center for Biotechnology Information
language English
publishDate 2018
record_format MEDLINE/PubMed
spelling pubmed-61286952018-09-07 Epigenetic regulation of Fgf1 transcription by CRTC1 and memory enhancement Uchida, Shusaku Shumyatsky, Gleb P. Brain Res Bull Article Recent evidence demonstrates that epigenetic regulation of gene transcription is critically involved in learning and memory. Here, we discuss the role of histone acetylation and DNA methylation, which are two best understood epigenetic processes in memory processes. More specifically, we focus on learning-strength-dependent changes in chromatin on the fibroblast growth factor 1 (Fgf1) gene and on the molecular events that modulate regulation of Fgf1 transcription, required for memory enhancement, with the specific focus on CREB-regulated transcription coactivator 1 (CRTC1). 2018-03-02 2018-07 /pmc/articles/PMC6128695/ /pubmed/29477835 http://dx.doi.org/10.1016/j.brainresbull.2018.02.016 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Uchida, Shusaku
Shumyatsky, Gleb P.
Epigenetic regulation of Fgf1 transcription by CRTC1 and memory enhancement
title Epigenetic regulation of Fgf1 transcription by CRTC1 and memory enhancement
title_full Epigenetic regulation of Fgf1 transcription by CRTC1 and memory enhancement
title_fullStr Epigenetic regulation of Fgf1 transcription by CRTC1 and memory enhancement
title_full_unstemmed Epigenetic regulation of Fgf1 transcription by CRTC1 and memory enhancement
title_short Epigenetic regulation of Fgf1 transcription by CRTC1 and memory enhancement
title_sort epigenetic regulation of fgf1 transcription by crtc1 and memory enhancement
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128695/
https://www.ncbi.nlm.nih.gov/pubmed/29477835
http://dx.doi.org/10.1016/j.brainresbull.2018.02.016
work_keys_str_mv AT uchidashusaku epigeneticregulationoffgf1transcriptionbycrtc1andmemoryenhancement
AT shumyatskyglebp epigeneticregulationoffgf1transcriptionbycrtc1andmemoryenhancement

Ejemplares similares