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High-throughput chromatin accessibility profiling at single-cell resolution

Here we develop a high-throughput single-cell ATAC-seq (assay for transposition of accessible chromatin) method to measure physical access to DNA in whole cells. Our approach integrates fluorescence imaging and addressable reagent deposition across a massively parallel (5184) nano-well array, yieldi...

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Detalles Bibliográficos
Autores principales:	Mezger, Anja, Klemm, Sandy, Mann, Ishminder, Brower, Kara, Mir, Alain, Bostick, Magnolia, Farmer, Andrew, Fordyce, Polly, Linnarsson, Sten, Greenleaf, William
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128862/ https://www.ncbi.nlm.nih.gov/pubmed/30194434 http://dx.doi.org/10.1038/s41467-018-05887-x

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