Cargando…

PIWI genes and piRNAs are ubiquitously expressed in mollusks and show patterns of lineage-specific adaptation

PIWI proteins and PIWI-interacting RNAs (piRNAs) suppress transposon activity in animals, thus protecting their genomes from detrimental insertion mutagenesis. Here, we reveal that PIWI genes and piRNAs are ubiquitously expressed in mollusks, similar to the situation in arthropods. We describe linea...

Descripción completa

Detalles Bibliográficos
Autores principales: Jehn, Julia, Gebert, Daniel, Pipilescu, Frank, Stern, Sarah, Kiefer, Julian Simon Thilo, Hewel, Charlotte, Rosenkranz, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128900/
https://www.ncbi.nlm.nih.gov/pubmed/30272016
http://dx.doi.org/10.1038/s42003-018-0141-4
_version_ 1783353718958194688
author Jehn, Julia
Gebert, Daniel
Pipilescu, Frank
Stern, Sarah
Kiefer, Julian Simon Thilo
Hewel, Charlotte
Rosenkranz, David
author_facet Jehn, Julia
Gebert, Daniel
Pipilescu, Frank
Stern, Sarah
Kiefer, Julian Simon Thilo
Hewel, Charlotte
Rosenkranz, David
author_sort Jehn, Julia
collection PubMed
description PIWI proteins and PIWI-interacting RNAs (piRNAs) suppress transposon activity in animals, thus protecting their genomes from detrimental insertion mutagenesis. Here, we reveal that PIWI genes and piRNAs are ubiquitously expressed in mollusks, similar to the situation in arthropods. We describe lineage-specific adaptations of transposon composition in piRNA clusters in the great pond snail and the pacific oyster, likely reflecting differential transposon activity in gastropods and bivalves. We further show that different piRNA clusters with unique transposon composition are dynamically expressed during oyster development. Finally, bioinformatics analyses suggest that different populations of piRNAs presumably bound to different PIWI paralogs participate in homotypic and heterotypic ping-pong amplification loops in a tissue- and sex-specific manner. Together with recent findings from other animal species, our results support the idea that somatic piRNA expression represents the ancestral state in metazoans.
format Online
Article
Text
id pubmed-6128900
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-61289002018-09-28 PIWI genes and piRNAs are ubiquitously expressed in mollusks and show patterns of lineage-specific adaptation Jehn, Julia Gebert, Daniel Pipilescu, Frank Stern, Sarah Kiefer, Julian Simon Thilo Hewel, Charlotte Rosenkranz, David Commun Biol Article PIWI proteins and PIWI-interacting RNAs (piRNAs) suppress transposon activity in animals, thus protecting their genomes from detrimental insertion mutagenesis. Here, we reveal that PIWI genes and piRNAs are ubiquitously expressed in mollusks, similar to the situation in arthropods. We describe lineage-specific adaptations of transposon composition in piRNA clusters in the great pond snail and the pacific oyster, likely reflecting differential transposon activity in gastropods and bivalves. We further show that different piRNA clusters with unique transposon composition are dynamically expressed during oyster development. Finally, bioinformatics analyses suggest that different populations of piRNAs presumably bound to different PIWI paralogs participate in homotypic and heterotypic ping-pong amplification loops in a tissue- and sex-specific manner. Together with recent findings from other animal species, our results support the idea that somatic piRNA expression represents the ancestral state in metazoans. Nature Publishing Group UK 2018-09-07 /pmc/articles/PMC6128900/ /pubmed/30272016 http://dx.doi.org/10.1038/s42003-018-0141-4 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Jehn, Julia
Gebert, Daniel
Pipilescu, Frank
Stern, Sarah
Kiefer, Julian Simon Thilo
Hewel, Charlotte
Rosenkranz, David
PIWI genes and piRNAs are ubiquitously expressed in mollusks and show patterns of lineage-specific adaptation
title PIWI genes and piRNAs are ubiquitously expressed in mollusks and show patterns of lineage-specific adaptation
title_full PIWI genes and piRNAs are ubiquitously expressed in mollusks and show patterns of lineage-specific adaptation
title_fullStr PIWI genes and piRNAs are ubiquitously expressed in mollusks and show patterns of lineage-specific adaptation
title_full_unstemmed PIWI genes and piRNAs are ubiquitously expressed in mollusks and show patterns of lineage-specific adaptation
title_short PIWI genes and piRNAs are ubiquitously expressed in mollusks and show patterns of lineage-specific adaptation
title_sort piwi genes and pirnas are ubiquitously expressed in mollusks and show patterns of lineage-specific adaptation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128900/
https://www.ncbi.nlm.nih.gov/pubmed/30272016
http://dx.doi.org/10.1038/s42003-018-0141-4
work_keys_str_mv AT jehnjulia piwigenesandpirnasareubiquitouslyexpressedinmollusksandshowpatternsoflineagespecificadaptation
AT gebertdaniel piwigenesandpirnasareubiquitouslyexpressedinmollusksandshowpatternsoflineagespecificadaptation
AT pipilescufrank piwigenesandpirnasareubiquitouslyexpressedinmollusksandshowpatternsoflineagespecificadaptation
AT sternsarah piwigenesandpirnasareubiquitouslyexpressedinmollusksandshowpatternsoflineagespecificadaptation
AT kieferjuliansimonthilo piwigenesandpirnasareubiquitouslyexpressedinmollusksandshowpatternsoflineagespecificadaptation
AT hewelcharlotte piwigenesandpirnasareubiquitouslyexpressedinmollusksandshowpatternsoflineagespecificadaptation
AT rosenkranzdavid piwigenesandpirnasareubiquitouslyexpressedinmollusksandshowpatternsoflineagespecificadaptation