Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells

Haploinsufficiency and aneuploidy are two phenomena, where gene dosage alterations cause severe defects ultimately resulting in developmental failures and disease. One remarkable exception is the X chromosome, where copy number differences between sexes are buffered by dosage compensation systems. I...

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Detalles Bibliográficos
Autores principales: Valsecchi, Claudia Isabelle Keller, Basilicata, M. Felicia, Semplicio, Giuseppe, Georgiev, Plamen, Gutierrez, Noel Marie, Akhtar, Asifa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128902/
https://www.ncbi.nlm.nih.gov/pubmed/30194291
http://dx.doi.org/10.1038/s41467-018-05642-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128902/
https://www.ncbi.nlm.nih.gov/pubmed/30194291
http://dx.doi.org/10.1038/s41467-018-05642-2

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