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Longitudinal body weight and sputum conversion in patients with tuberculosis, Southwest Ethiopia: a retrospective follow-up study

OBJECTIVES: To describe the association between change in body weight and sputum smear conversion and to identify factors linked with body weight and sputum smear conversion in Jimma University Specialized Hospital, Southwest Ethiopia. DESIGN: A retrospective follow-up study. SETTING: Teaching hospi...

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Autores principales: Filate, Mersha, Mehari, Zelalem, Alemu, Yihun Mulugeta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129038/
https://www.ncbi.nlm.nih.gov/pubmed/30185566
http://dx.doi.org/10.1136/bmjopen-2017-019076
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author Filate, Mersha
Mehari, Zelalem
Alemu, Yihun Mulugeta
author_facet Filate, Mersha
Mehari, Zelalem
Alemu, Yihun Mulugeta
author_sort Filate, Mersha
collection PubMed
description OBJECTIVES: To describe the association between change in body weight and sputum smear conversion and to identify factors linked with body weight and sputum smear conversion in Jimma University Specialized Hospital, Southwest Ethiopia. DESIGN: A retrospective follow-up study. SETTING: Teaching hospital in Southwest Ethiopia. PARTICIPANTS: A total of 450 patients with tuberculosis (TB) were included in the follow-up between 2011 and 2013. MAIN OUTCOME MEASURES: The association between body weight and sputum conversion was measured using joint modelling. RESULTS: The association between change in body weight and change in sputum conversion was −0.698 (p<0.001). A strong inverse association between change in body weight and change in sputum conversion was observed. The study variables sex, age, type of TB, HIV status, dose of anti-TB drug and length of enrolment to TB treatment were significantly associated with change in body weight of patients with TB. The study variables age, type of TB, dose of anti-TB drug and length of enrolment were significantly associated with change in sputum status of patients with TB. CONCLUSIONS: Among patients with TB who were on anti-TB treatment, increase in body weight and positive sputum status were inversely related over time. TB prevention and control strategies should give emphasis on factors such as female sex, older age, non-pulmonary positive type of TB, HIV-positive, lower dose of anti-TB drug and length of enrolment to TB treatment during monitoring of trends in body weight and sputum status.
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spelling pubmed-61290382018-09-10 Longitudinal body weight and sputum conversion in patients with tuberculosis, Southwest Ethiopia: a retrospective follow-up study Filate, Mersha Mehari, Zelalem Alemu, Yihun Mulugeta BMJ Open Epidemiology OBJECTIVES: To describe the association between change in body weight and sputum smear conversion and to identify factors linked with body weight and sputum smear conversion in Jimma University Specialized Hospital, Southwest Ethiopia. DESIGN: A retrospective follow-up study. SETTING: Teaching hospital in Southwest Ethiopia. PARTICIPANTS: A total of 450 patients with tuberculosis (TB) were included in the follow-up between 2011 and 2013. MAIN OUTCOME MEASURES: The association between body weight and sputum conversion was measured using joint modelling. RESULTS: The association between change in body weight and change in sputum conversion was −0.698 (p<0.001). A strong inverse association between change in body weight and change in sputum conversion was observed. The study variables sex, age, type of TB, HIV status, dose of anti-TB drug and length of enrolment to TB treatment were significantly associated with change in body weight of patients with TB. The study variables age, type of TB, dose of anti-TB drug and length of enrolment were significantly associated with change in sputum status of patients with TB. CONCLUSIONS: Among patients with TB who were on anti-TB treatment, increase in body weight and positive sputum status were inversely related over time. TB prevention and control strategies should give emphasis on factors such as female sex, older age, non-pulmonary positive type of TB, HIV-positive, lower dose of anti-TB drug and length of enrolment to TB treatment during monitoring of trends in body weight and sputum status. BMJ Publishing Group 2018-09-05 /pmc/articles/PMC6129038/ /pubmed/30185566 http://dx.doi.org/10.1136/bmjopen-2017-019076 Text en © Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Epidemiology
Filate, Mersha
Mehari, Zelalem
Alemu, Yihun Mulugeta
Longitudinal body weight and sputum conversion in patients with tuberculosis, Southwest Ethiopia: a retrospective follow-up study
title Longitudinal body weight and sputum conversion in patients with tuberculosis, Southwest Ethiopia: a retrospective follow-up study
title_full Longitudinal body weight and sputum conversion in patients with tuberculosis, Southwest Ethiopia: a retrospective follow-up study
title_fullStr Longitudinal body weight and sputum conversion in patients with tuberculosis, Southwest Ethiopia: a retrospective follow-up study
title_full_unstemmed Longitudinal body weight and sputum conversion in patients with tuberculosis, Southwest Ethiopia: a retrospective follow-up study
title_short Longitudinal body weight and sputum conversion in patients with tuberculosis, Southwest Ethiopia: a retrospective follow-up study
title_sort longitudinal body weight and sputum conversion in patients with tuberculosis, southwest ethiopia: a retrospective follow-up study
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129038/
https://www.ncbi.nlm.nih.gov/pubmed/30185566
http://dx.doi.org/10.1136/bmjopen-2017-019076
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