Experimental Microbial Dysbiosis Does Not Promote Disease Progression in SIV-Infected Macaques

Intestinal microbial dysbiosis has been described in HIV-1-infected individuals and may underlie persistent inflammation in chronic infection, thereby contributing to disease progression. Herein, we induced an HIV-1-like intestinal dysbiosis in rhesus macaques with vancomycin treatment and assessed...

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Detalles Bibliográficos
Autores principales: Ortiz, Alexandra M., Flynn, Jacob K., DiNapoli, Sarah R., Vujkovic-Cvijin, Ivan, Starke, Carly Elizabeth C., Lai, Stephen H., Long, MacKenzie E., Sortino, Ornella, Vinton, Carol L., Mudd, Joseph C., Johnston, Leslie, Busman-Sahay, Kathleen, Belkaid, Yasmine, Estes, Jacob D., Brenchley, Jason M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129204/
https://www.ncbi.nlm.nih.gov/pubmed/30061696
http://dx.doi.org/10.1038/s41591-018-0132-5
Descripción
Sumario:Intestinal microbial dysbiosis has been described in HIV-1-infected individuals and may underlie persistent inflammation in chronic infection, thereby contributing to disease progression. Herein, we induced an HIV-1-like intestinal dysbiosis in rhesus macaques with vancomycin treatment and assessed the contribution of dysbiosis to SIV disease progression. Dysbiotic and control animals had similar disease progression, indicating that intestinal microbial dysbiosis similar to that observed in HIV-infected individuals is not sufficient to accelerate untreated lentiviral disease progression.

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