Cargando…
Experimental Microbial Dysbiosis Does Not Promote Disease Progression in SIV-Infected Macaques
Intestinal microbial dysbiosis has been described in HIV-1-infected individuals and may underlie persistent inflammation in chronic infection, thereby contributing to disease progression. Herein, we induced an HIV-1-like intestinal dysbiosis in rhesus macaques with vancomycin treatment and assessed...
| Autores principales: | , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129204/ https://www.ncbi.nlm.nih.gov/pubmed/30061696 http://dx.doi.org/10.1038/s41591-018-0132-5 |
| _version_ | 1783353766506921984 |
|---|---|
| author | Ortiz, Alexandra M. Flynn, Jacob K. DiNapoli, Sarah R. Vujkovic-Cvijin, Ivan Starke, Carly Elizabeth C. Lai, Stephen H. Long, MacKenzie E. Sortino, Ornella Vinton, Carol L. Mudd, Joseph C. Johnston, Leslie Busman-Sahay, Kathleen Belkaid, Yasmine Estes, Jacob D. Brenchley, Jason M. |
| author_facet | Ortiz, Alexandra M. Flynn, Jacob K. DiNapoli, Sarah R. Vujkovic-Cvijin, Ivan Starke, Carly Elizabeth C. Lai, Stephen H. Long, MacKenzie E. Sortino, Ornella Vinton, Carol L. Mudd, Joseph C. Johnston, Leslie Busman-Sahay, Kathleen Belkaid, Yasmine Estes, Jacob D. Brenchley, Jason M. |
| author_sort | Ortiz, Alexandra M. |
| collection | PubMed |
| description | Intestinal microbial dysbiosis has been described in HIV-1-infected individuals and may underlie persistent inflammation in chronic infection, thereby contributing to disease progression. Herein, we induced an HIV-1-like intestinal dysbiosis in rhesus macaques with vancomycin treatment and assessed the contribution of dysbiosis to SIV disease progression. Dysbiotic and control animals had similar disease progression, indicating that intestinal microbial dysbiosis similar to that observed in HIV-infected individuals is not sufficient to accelerate untreated lentiviral disease progression. |
| format | Online Article Text |
| id | pubmed-6129204 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-61292042019-01-30 Experimental Microbial Dysbiosis Does Not Promote Disease Progression in SIV-Infected Macaques Ortiz, Alexandra M. Flynn, Jacob K. DiNapoli, Sarah R. Vujkovic-Cvijin, Ivan Starke, Carly Elizabeth C. Lai, Stephen H. Long, MacKenzie E. Sortino, Ornella Vinton, Carol L. Mudd, Joseph C. Johnston, Leslie Busman-Sahay, Kathleen Belkaid, Yasmine Estes, Jacob D. Brenchley, Jason M. Nat Med Article Intestinal microbial dysbiosis has been described in HIV-1-infected individuals and may underlie persistent inflammation in chronic infection, thereby contributing to disease progression. Herein, we induced an HIV-1-like intestinal dysbiosis in rhesus macaques with vancomycin treatment and assessed the contribution of dysbiosis to SIV disease progression. Dysbiotic and control animals had similar disease progression, indicating that intestinal microbial dysbiosis similar to that observed in HIV-infected individuals is not sufficient to accelerate untreated lentiviral disease progression. 2018-07-30 2018-09 /pmc/articles/PMC6129204/ /pubmed/30061696 http://dx.doi.org/10.1038/s41591-018-0132-5 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Ortiz, Alexandra M. Flynn, Jacob K. DiNapoli, Sarah R. Vujkovic-Cvijin, Ivan Starke, Carly Elizabeth C. Lai, Stephen H. Long, MacKenzie E. Sortino, Ornella Vinton, Carol L. Mudd, Joseph C. Johnston, Leslie Busman-Sahay, Kathleen Belkaid, Yasmine Estes, Jacob D. Brenchley, Jason M. Experimental Microbial Dysbiosis Does Not Promote Disease Progression in SIV-Infected Macaques |
| title | Experimental Microbial Dysbiosis Does Not Promote Disease Progression in SIV-Infected Macaques |
| title_full | Experimental Microbial Dysbiosis Does Not Promote Disease Progression in SIV-Infected Macaques |
| title_fullStr | Experimental Microbial Dysbiosis Does Not Promote Disease Progression in SIV-Infected Macaques |
| title_full_unstemmed | Experimental Microbial Dysbiosis Does Not Promote Disease Progression in SIV-Infected Macaques |
| title_short | Experimental Microbial Dysbiosis Does Not Promote Disease Progression in SIV-Infected Macaques |
| title_sort | experimental microbial dysbiosis does not promote disease progression in siv-infected macaques |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129204/ https://www.ncbi.nlm.nih.gov/pubmed/30061696 http://dx.doi.org/10.1038/s41591-018-0132-5 |
| work_keys_str_mv | AT ortizalexandram experimentalmicrobialdysbiosisdoesnotpromotediseaseprogressioninsivinfectedmacaques AT flynnjacobk experimentalmicrobialdysbiosisdoesnotpromotediseaseprogressioninsivinfectedmacaques AT dinapolisarahr experimentalmicrobialdysbiosisdoesnotpromotediseaseprogressioninsivinfectedmacaques AT vujkoviccvijinivan experimentalmicrobialdysbiosisdoesnotpromotediseaseprogressioninsivinfectedmacaques AT starkecarlyelizabethc experimentalmicrobialdysbiosisdoesnotpromotediseaseprogressioninsivinfectedmacaques AT laistephenh experimentalmicrobialdysbiosisdoesnotpromotediseaseprogressioninsivinfectedmacaques AT longmackenziee experimentalmicrobialdysbiosisdoesnotpromotediseaseprogressioninsivinfectedmacaques AT sortinoornella experimentalmicrobialdysbiosisdoesnotpromotediseaseprogressioninsivinfectedmacaques AT vintoncaroll experimentalmicrobialdysbiosisdoesnotpromotediseaseprogressioninsivinfectedmacaques AT muddjosephc experimentalmicrobialdysbiosisdoesnotpromotediseaseprogressioninsivinfectedmacaques AT johnstonleslie experimentalmicrobialdysbiosisdoesnotpromotediseaseprogressioninsivinfectedmacaques AT busmansahaykathleen experimentalmicrobialdysbiosisdoesnotpromotediseaseprogressioninsivinfectedmacaques AT belkaidyasmine experimentalmicrobialdysbiosisdoesnotpromotediseaseprogressioninsivinfectedmacaques AT estesjacobd experimentalmicrobialdysbiosisdoesnotpromotediseaseprogressioninsivinfectedmacaques AT brenchleyjasonm experimentalmicrobialdysbiosisdoesnotpromotediseaseprogressioninsivinfectedmacaques |