Inhibitory Activity and Docking Analysis of Antimalarial Agents from Stemona sp. toward Ferredoxin-NADP+ Reductase from Malaria Parasites

Ferredoxin-NADP(+) reductases (FNRs, EC 1.18.1.2) were found in the plastids of Plasmodium and have been considered as a target for the development of new antimalarial agents. Croomine, epi-croomine, tuberostemonine, javastemonine A, and isoprotostemonine are isolated alkaloids from the roots of Ste...

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Autores principales: Pudjiastuti, Pratiwi, Puspaningsih, Ni Nyoman T., Siswanto, Imam, Fanani, Much. Z., Ariga, Yoko K., Hase, Toshiharu, Sarker, Satyajit D., Nahar, Lutfun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129339/
https://www.ncbi.nlm.nih.gov/pubmed/30225138
http://dx.doi.org/10.1155/2018/3469132
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author Pudjiastuti, Pratiwi
Puspaningsih, Ni Nyoman T.
Siswanto, Imam
Fanani, Much. Z.
Ariga, Yoko K.
Hase, Toshiharu
Sarker, Satyajit D.
Nahar, Lutfun
author_facet Pudjiastuti, Pratiwi
Puspaningsih, Ni Nyoman T.
Siswanto, Imam
Fanani, Much. Z.
Ariga, Yoko K.
Hase, Toshiharu
Sarker, Satyajit D.
Nahar, Lutfun
author_sort Pudjiastuti, Pratiwi
collection PubMed
description Ferredoxin-NADP(+) reductases (FNRs, EC 1.18.1.2) were found in the plastids of Plasmodium and have been considered as a target for the development of new antimalarial agents. Croomine, epi-croomine, tuberostemonine, javastemonine A, and isoprotostemonine are isolated alkaloids from the roots of Stemona sp. and their inhibitory effect on FNRs from Plasmodium falciparum (PfFNR) was investigated. Croomine showed the highest level of inhibition (33.9%) of electron transfer from PfFNR to PfFd, while tuberstemonine displayed the highest level of inhibition (55.4%) of diaphorase activity of PfFNR. Docking analysis represented that croomine is located at the middle position of PfFNR and PfFd. Croomine from S. tuberosa appeared to have potential as an antimalarial agent.
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spelling pubmed-61293392018-09-17 Inhibitory Activity and Docking Analysis of Antimalarial Agents from Stemona sp. toward Ferredoxin-NADP+ Reductase from Malaria Parasites Pudjiastuti, Pratiwi Puspaningsih, Ni Nyoman T. Siswanto, Imam Fanani, Much. Z. Ariga, Yoko K. Hase, Toshiharu Sarker, Satyajit D. Nahar, Lutfun J Parasitol Res Research Article Ferredoxin-NADP(+) reductases (FNRs, EC 1.18.1.2) were found in the plastids of Plasmodium and have been considered as a target for the development of new antimalarial agents. Croomine, epi-croomine, tuberostemonine, javastemonine A, and isoprotostemonine are isolated alkaloids from the roots of Stemona sp. and their inhibitory effect on FNRs from Plasmodium falciparum (PfFNR) was investigated. Croomine showed the highest level of inhibition (33.9%) of electron transfer from PfFNR to PfFd, while tuberstemonine displayed the highest level of inhibition (55.4%) of diaphorase activity of PfFNR. Docking analysis represented that croomine is located at the middle position of PfFNR and PfFd. Croomine from S. tuberosa appeared to have potential as an antimalarial agent. Hindawi 2018-08-26 /pmc/articles/PMC6129339/ /pubmed/30225138 http://dx.doi.org/10.1155/2018/3469132 Text en Copyright © 2018 Pratiwi Pudjiastuti et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Pudjiastuti, Pratiwi
Puspaningsih, Ni Nyoman T.
Siswanto, Imam
Fanani, Much. Z.
Ariga, Yoko K.
Hase, Toshiharu
Sarker, Satyajit D.
Nahar, Lutfun
Inhibitory Activity and Docking Analysis of Antimalarial Agents from Stemona sp. toward Ferredoxin-NADP+ Reductase from Malaria Parasites
title Inhibitory Activity and Docking Analysis of Antimalarial Agents from Stemona sp. toward Ferredoxin-NADP+ Reductase from Malaria Parasites
title_full Inhibitory Activity and Docking Analysis of Antimalarial Agents from Stemona sp. toward Ferredoxin-NADP+ Reductase from Malaria Parasites
title_fullStr Inhibitory Activity and Docking Analysis of Antimalarial Agents from Stemona sp. toward Ferredoxin-NADP+ Reductase from Malaria Parasites
title_full_unstemmed Inhibitory Activity and Docking Analysis of Antimalarial Agents from Stemona sp. toward Ferredoxin-NADP+ Reductase from Malaria Parasites
title_short Inhibitory Activity and Docking Analysis of Antimalarial Agents from Stemona sp. toward Ferredoxin-NADP+ Reductase from Malaria Parasites
title_sort inhibitory activity and docking analysis of antimalarial agents from stemona sp. toward ferredoxin-nadp+ reductase from malaria parasites
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129339/
https://www.ncbi.nlm.nih.gov/pubmed/30225138
http://dx.doi.org/10.1155/2018/3469132
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