Clinical significance of Th17 cells in kidney transplantation

Transplantation research has focused on cytotoxic T-cell and plasma cell/B-cell-targeted strategies, but little attention has been paid to the role of T helper 17 (Th17) cells in allograft dysfunction. However, accumulating evidence suggests that Th17 cells contribute to the development of acute and...

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Detalles Bibliográficos
Autores principales: Chung, Byung Ha, Yang, Chul Woo, Cho, Mi-La
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Internal Medicine 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129639/
https://www.ncbi.nlm.nih.gov/pubmed/29843491
http://dx.doi.org/10.3904/kjim.2018.095
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author Chung, Byung Ha
Yang, Chul Woo
Cho, Mi-La
author_facet Chung, Byung Ha
Yang, Chul Woo
Cho, Mi-La
author_sort Chung, Byung Ha
collection PubMed
description Transplantation research has focused on cytotoxic T-cell and plasma cell/B-cell-targeted strategies, but little attention has been paid to the role of T helper 17 (Th17) cells in allograft dysfunction. However, accumulating evidence suggests that Th17 cells contribute to the development of acute and chronic allograft injury after transplantation of various organs, including the kidney. This review summarizes recent reports on the role of Th17 cells in kidney transplantation. Means of improving allograft outcomes by targeting the Th17 pathway are also suggested.
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spelling pubmed-61296392018-09-11 Clinical significance of Th17 cells in kidney transplantation Chung, Byung Ha Yang, Chul Woo Cho, Mi-La Korean J Intern Med Review Transplantation research has focused on cytotoxic T-cell and plasma cell/B-cell-targeted strategies, but little attention has been paid to the role of T helper 17 (Th17) cells in allograft dysfunction. However, accumulating evidence suggests that Th17 cells contribute to the development of acute and chronic allograft injury after transplantation of various organs, including the kidney. This review summarizes recent reports on the role of Th17 cells in kidney transplantation. Means of improving allograft outcomes by targeting the Th17 pathway are also suggested. The Korean Association of Internal Medicine 2018-09 2018-05-31 /pmc/articles/PMC6129639/ /pubmed/29843491 http://dx.doi.org/10.3904/kjim.2018.095 Text en Copyright © 2018 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Chung, Byung Ha
Yang, Chul Woo
Cho, Mi-La
Clinical significance of Th17 cells in kidney transplantation
title Clinical significance of Th17 cells in kidney transplantation
title_full Clinical significance of Th17 cells in kidney transplantation
title_fullStr Clinical significance of Th17 cells in kidney transplantation
title_full_unstemmed Clinical significance of Th17 cells in kidney transplantation
title_short Clinical significance of Th17 cells in kidney transplantation
title_sort clinical significance of th17 cells in kidney transplantation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129639/
https://www.ncbi.nlm.nih.gov/pubmed/29843491
http://dx.doi.org/10.3904/kjim.2018.095
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