Systemic neutrophil migration and rapid consumption of neutrophils in the spleen

The systemic migration of neutrophils is not fully understood. In this study, we purified neutrophils from rat peripheral blood and labeled them with [(51)Cr] sodium chromate. The labeled cells were injected into the tail veins of rats, and were traced. Neutrophils were rapidly trapped in the liver...

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Autores principales: Takeda, Yuji, Kato, Tomoyuki, Nemoto, Nobuhito, Araki, Akemi, Gazi, Mohammad Yeashin, Nara, Hidetoshi, Asao, Hironobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Physics and Astronomy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129690/
https://www.ncbi.nlm.nih.gov/pubmed/30211259
http://dx.doi.org/10.1016/j.dib.2018.08.090
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author Takeda, Yuji
Kato, Tomoyuki
Nemoto, Nobuhito
Araki, Akemi
Gazi, Mohammad Yeashin
Nara, Hidetoshi
Asao, Hironobu
author_facet Takeda, Yuji
Kato, Tomoyuki
Nemoto, Nobuhito
Araki, Akemi
Gazi, Mohammad Yeashin
Nara, Hidetoshi
Asao, Hironobu
author_sort Takeda, Yuji
collection PubMed
description The systemic migration of neutrophils is not fully understood. In this study, we purified neutrophils from rat peripheral blood and labeled them with [(51)Cr] sodium chromate. The labeled cells were injected into the tail veins of rats, and were traced. Neutrophils were rapidly trapped in the liver and the spleen within 6 h. The migration ratios of neutrophils in the lung and the gut were lower compared with those in the liver and the spleen. Interestingly, migrated cells into the spleen were rapidly phagocytosed by monocytes/macrophages. Therefore, accumulation of intact neutrophils in the spleen may be difficult to measure.
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spelling pubmed-61296902018-09-12 Systemic neutrophil migration and rapid consumption of neutrophils in the spleen Takeda, Yuji Kato, Tomoyuki Nemoto, Nobuhito Araki, Akemi Gazi, Mohammad Yeashin Nara, Hidetoshi Asao, Hironobu Data Brief Physics and Astronomy The systemic migration of neutrophils is not fully understood. In this study, we purified neutrophils from rat peripheral blood and labeled them with [(51)Cr] sodium chromate. The labeled cells were injected into the tail veins of rats, and were traced. Neutrophils were rapidly trapped in the liver and the spleen within 6 h. The migration ratios of neutrophils in the lung and the gut were lower compared with those in the liver and the spleen. Interestingly, migrated cells into the spleen were rapidly phagocytosed by monocytes/macrophages. Therefore, accumulation of intact neutrophils in the spleen may be difficult to measure. Elsevier 2018-08-30 /pmc/articles/PMC6129690/ /pubmed/30211259 http://dx.doi.org/10.1016/j.dib.2018.08.090 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Physics and Astronomy
Takeda, Yuji
Kato, Tomoyuki
Nemoto, Nobuhito
Araki, Akemi
Gazi, Mohammad Yeashin
Nara, Hidetoshi
Asao, Hironobu
Systemic neutrophil migration and rapid consumption of neutrophils in the spleen
title Systemic neutrophil migration and rapid consumption of neutrophils in the spleen
title_full Systemic neutrophil migration and rapid consumption of neutrophils in the spleen
title_fullStr Systemic neutrophil migration and rapid consumption of neutrophils in the spleen
title_full_unstemmed Systemic neutrophil migration and rapid consumption of neutrophils in the spleen
title_short Systemic neutrophil migration and rapid consumption of neutrophils in the spleen
title_sort systemic neutrophil migration and rapid consumption of neutrophils in the spleen
topic Physics and Astronomy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129690/
https://www.ncbi.nlm.nih.gov/pubmed/30211259
http://dx.doi.org/10.1016/j.dib.2018.08.090
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