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Changes in Intracortical Excitability of Affected and Unaffected Hemispheres After Stroke Evaluated by Paired-Pulse Transcranial Magnetic Stimulation
OBJECTIVE: To assess the altered pattern of intracortical excitability of the affected and unaffected hemispheres in stroke patients using paired-pulse transcranial magnetic stimulation (TMS). METHODS: We evaluated intracortical inhibition (ICI) and intracortical facilitation (ICF) in both hemispher...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Academy of Rehabilitation Medicine
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129700/ https://www.ncbi.nlm.nih.gov/pubmed/30180517 http://dx.doi.org/10.5535/arm.2018.42.4.495 |
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author | Seo, Ho Youn Kim, Gi-Wook Won, Yu Hui Park, Sung-Hee Seo, Jeong-Hwan Ko, Myoung-Hwan |
author_facet | Seo, Ho Youn Kim, Gi-Wook Won, Yu Hui Park, Sung-Hee Seo, Jeong-Hwan Ko, Myoung-Hwan |
author_sort | Seo, Ho Youn |
collection | PubMed |
description | OBJECTIVE: To assess the altered pattern of intracortical excitability of the affected and unaffected hemispheres in stroke patients using paired-pulse transcranial magnetic stimulation (TMS). METHODS: We evaluated intracortical inhibition (ICI) and intracortical facilitation (ICF) in both hemispheres at acute and subacute stages of 103 stroke patients using paired-pulse TMS. The patients were divided into two groups: mild-to-moderate patients whose motor evoked potential (MEP) was recorded in the affected hemisphere; and severe patients whose MEP was not recorded in the affected hemisphere. RESULTS: In mild-to-moderate patients, the value of ICI in the affected hemisphere was increased from 70.3% to 77.9% and the value of ICI in the unaffected hemisphere was decreased from 74.8% to 70.3% with eventual progression in acute to subacute stages of stroke. In severe patients, the value of ICI in the unaffected hemisphere was increased from 65.4% to 75.6%. The changes in ICF were not significantly different in this study. CONCLUSION: We conclude that the unaffected hemisphere was more disinhibited than the affected hemisphere in acute phase of mild-to-moderate stroke, and the affected hemisphere was more disinhibited in the subacute stage. The unaffected hemisphere was inhibited in severe cases in acute-to-subacute phases of stroke. This finding facilitates appropriate neuromodulation of acute-to-subacute phases in mild-to-severe stroke patients. |
format | Online Article Text |
id | pubmed-6129700 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Korean Academy of Rehabilitation Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-61297002018-09-11 Changes in Intracortical Excitability of Affected and Unaffected Hemispheres After Stroke Evaluated by Paired-Pulse Transcranial Magnetic Stimulation Seo, Ho Youn Kim, Gi-Wook Won, Yu Hui Park, Sung-Hee Seo, Jeong-Hwan Ko, Myoung-Hwan Ann Rehabil Med Original Article OBJECTIVE: To assess the altered pattern of intracortical excitability of the affected and unaffected hemispheres in stroke patients using paired-pulse transcranial magnetic stimulation (TMS). METHODS: We evaluated intracortical inhibition (ICI) and intracortical facilitation (ICF) in both hemispheres at acute and subacute stages of 103 stroke patients using paired-pulse TMS. The patients were divided into two groups: mild-to-moderate patients whose motor evoked potential (MEP) was recorded in the affected hemisphere; and severe patients whose MEP was not recorded in the affected hemisphere. RESULTS: In mild-to-moderate patients, the value of ICI in the affected hemisphere was increased from 70.3% to 77.9% and the value of ICI in the unaffected hemisphere was decreased from 74.8% to 70.3% with eventual progression in acute to subacute stages of stroke. In severe patients, the value of ICI in the unaffected hemisphere was increased from 65.4% to 75.6%. The changes in ICF were not significantly different in this study. CONCLUSION: We conclude that the unaffected hemisphere was more disinhibited than the affected hemisphere in acute phase of mild-to-moderate stroke, and the affected hemisphere was more disinhibited in the subacute stage. The unaffected hemisphere was inhibited in severe cases in acute-to-subacute phases of stroke. This finding facilitates appropriate neuromodulation of acute-to-subacute phases in mild-to-severe stroke patients. Korean Academy of Rehabilitation Medicine 2018-08 2018-08-31 /pmc/articles/PMC6129700/ /pubmed/30180517 http://dx.doi.org/10.5535/arm.2018.42.4.495 Text en Copyright © 2018 by Korean Academy of Rehabilitation Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Seo, Ho Youn Kim, Gi-Wook Won, Yu Hui Park, Sung-Hee Seo, Jeong-Hwan Ko, Myoung-Hwan Changes in Intracortical Excitability of Affected and Unaffected Hemispheres After Stroke Evaluated by Paired-Pulse Transcranial Magnetic Stimulation |
title | Changes in Intracortical Excitability of Affected and Unaffected Hemispheres After Stroke Evaluated by Paired-Pulse Transcranial Magnetic Stimulation |
title_full | Changes in Intracortical Excitability of Affected and Unaffected Hemispheres After Stroke Evaluated by Paired-Pulse Transcranial Magnetic Stimulation |
title_fullStr | Changes in Intracortical Excitability of Affected and Unaffected Hemispheres After Stroke Evaluated by Paired-Pulse Transcranial Magnetic Stimulation |
title_full_unstemmed | Changes in Intracortical Excitability of Affected and Unaffected Hemispheres After Stroke Evaluated by Paired-Pulse Transcranial Magnetic Stimulation |
title_short | Changes in Intracortical Excitability of Affected and Unaffected Hemispheres After Stroke Evaluated by Paired-Pulse Transcranial Magnetic Stimulation |
title_sort | changes in intracortical excitability of affected and unaffected hemispheres after stroke evaluated by paired-pulse transcranial magnetic stimulation |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129700/ https://www.ncbi.nlm.nih.gov/pubmed/30180517 http://dx.doi.org/10.5535/arm.2018.42.4.495 |
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