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The Effect of Polydeoxyribonucleotide on Chronic Non-healing Wound of an Amputee: A Case Report
Polydeoxyribonucleotide (PDRN) is safe and effective in wound healing, cellular growth, synthesis of extracellular matrix protein, and inflammation reduction via activation of adenosine A2 receptors. We report a 28-year-old male patient treated with PDRN injections for chronic non-healing wound refr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Academy of Rehabilitation Medicine
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129705/ https://www.ncbi.nlm.nih.gov/pubmed/30180535 http://dx.doi.org/10.5535/arm.2018.42.4.630 |
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author | Shin, Junho Park, Gahee Lee, Junhee Bae, Hasuk |
author_facet | Shin, Junho Park, Gahee Lee, Junhee Bae, Hasuk |
author_sort | Shin, Junho |
collection | PubMed |
description | Polydeoxyribonucleotide (PDRN) is safe and effective in wound healing, cellular growth, synthesis of extracellular matrix protein, and inflammation reduction via activation of adenosine A2 receptors. We report a 28-year-old male patient treated with PDRN injections for chronic non-healing wound refractory to negative pressure wound therapy, skin graft, or growth factors. Three injections of PDRN were administered at the wound site into the anterior and medial sides of the left stump on the 1st, 4th, and 9th days of hospitalization. The PDRN ameliorated wound healing by enhancing cell growth, tissue repair, and angiogenesis. PDRN application represents a potential treatment for non-healing wounds obviating the need for additional therapies, and hospitalization, as well as improve patient’s activities of daily living. |
format | Online Article Text |
id | pubmed-6129705 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Korean Academy of Rehabilitation Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-61297052018-09-11 The Effect of Polydeoxyribonucleotide on Chronic Non-healing Wound of an Amputee: A Case Report Shin, Junho Park, Gahee Lee, Junhee Bae, Hasuk Ann Rehabil Med Case Report Polydeoxyribonucleotide (PDRN) is safe and effective in wound healing, cellular growth, synthesis of extracellular matrix protein, and inflammation reduction via activation of adenosine A2 receptors. We report a 28-year-old male patient treated with PDRN injections for chronic non-healing wound refractory to negative pressure wound therapy, skin graft, or growth factors. Three injections of PDRN were administered at the wound site into the anterior and medial sides of the left stump on the 1st, 4th, and 9th days of hospitalization. The PDRN ameliorated wound healing by enhancing cell growth, tissue repair, and angiogenesis. PDRN application represents a potential treatment for non-healing wounds obviating the need for additional therapies, and hospitalization, as well as improve patient’s activities of daily living. Korean Academy of Rehabilitation Medicine 2018-08 2018-08-31 /pmc/articles/PMC6129705/ /pubmed/30180535 http://dx.doi.org/10.5535/arm.2018.42.4.630 Text en Copyright © 2018 by Korean Academy of Rehabilitation Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Shin, Junho Park, Gahee Lee, Junhee Bae, Hasuk The Effect of Polydeoxyribonucleotide on Chronic Non-healing Wound of an Amputee: A Case Report |
title | The Effect of Polydeoxyribonucleotide on Chronic Non-healing Wound of an Amputee: A Case Report |
title_full | The Effect of Polydeoxyribonucleotide on Chronic Non-healing Wound of an Amputee: A Case Report |
title_fullStr | The Effect of Polydeoxyribonucleotide on Chronic Non-healing Wound of an Amputee: A Case Report |
title_full_unstemmed | The Effect of Polydeoxyribonucleotide on Chronic Non-healing Wound of an Amputee: A Case Report |
title_short | The Effect of Polydeoxyribonucleotide on Chronic Non-healing Wound of an Amputee: A Case Report |
title_sort | effect of polydeoxyribonucleotide on chronic non-healing wound of an amputee: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129705/ https://www.ncbi.nlm.nih.gov/pubmed/30180535 http://dx.doi.org/10.5535/arm.2018.42.4.630 |
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