The effect of physical exercise on cerebral blood flow in Alzheimer's disease

In recent years there has been an increasing focus on the relation between cerebrovascular health, physical exercise and Alzheimer's disease. The aim of the current study was to determine the effect of moderate-to-high-intensity aerobic exercise on cerebral blood flow in patients with mild to m...

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Autores principales: van der Kleij, Lisa A., Petersen, Esben T., Siebner, Hartwig R., Hendrikse, Jeroen, Frederiksen, Kristian S., Sobol, Nanna A., Hasselbalch, Steen G., Garde, Ellen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129739/
https://www.ncbi.nlm.nih.gov/pubmed/30211001
http://dx.doi.org/10.1016/j.nicl.2018.09.003
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author van der Kleij, Lisa A.
Petersen, Esben T.
Siebner, Hartwig R.
Hendrikse, Jeroen
Frederiksen, Kristian S.
Sobol, Nanna A.
Hasselbalch, Steen G.
Garde, Ellen
author_facet van der Kleij, Lisa A.
Petersen, Esben T.
Siebner, Hartwig R.
Hendrikse, Jeroen
Frederiksen, Kristian S.
Sobol, Nanna A.
Hasselbalch, Steen G.
Garde, Ellen
author_sort van der Kleij, Lisa A.
collection PubMed
description In recent years there has been an increasing focus on the relation between cerebrovascular health, physical exercise and Alzheimer's disease. The aim of the current study was to determine the effect of moderate-to-high-intensity aerobic exercise on cerebral blood flow in patients with mild to moderate Alzheimer's disease. Fifty-one patients were randomized to either usual care or moderate-to-high intensity aerobic exercise for 16 weeks. Exercise had no consistent effect on whole brain or regional cerebral blood flow. Sixteen weeks of exercise are, therefore, not sufficient to produce a consistent increase in cerebral blood flow in a relatively small sample of Alzheimer's patients.
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spelling pubmed-61297392018-09-12 The effect of physical exercise on cerebral blood flow in Alzheimer's disease van der Kleij, Lisa A. Petersen, Esben T. Siebner, Hartwig R. Hendrikse, Jeroen Frederiksen, Kristian S. Sobol, Nanna A. Hasselbalch, Steen G. Garde, Ellen Neuroimage Clin Regular Article In recent years there has been an increasing focus on the relation between cerebrovascular health, physical exercise and Alzheimer's disease. The aim of the current study was to determine the effect of moderate-to-high-intensity aerobic exercise on cerebral blood flow in patients with mild to moderate Alzheimer's disease. Fifty-one patients were randomized to either usual care or moderate-to-high intensity aerobic exercise for 16 weeks. Exercise had no consistent effect on whole brain or regional cerebral blood flow. Sixteen weeks of exercise are, therefore, not sufficient to produce a consistent increase in cerebral blood flow in a relatively small sample of Alzheimer's patients. Elsevier 2018-09-04 /pmc/articles/PMC6129739/ /pubmed/30211001 http://dx.doi.org/10.1016/j.nicl.2018.09.003 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
van der Kleij, Lisa A.
Petersen, Esben T.
Siebner, Hartwig R.
Hendrikse, Jeroen
Frederiksen, Kristian S.
Sobol, Nanna A.
Hasselbalch, Steen G.
Garde, Ellen
The effect of physical exercise on cerebral blood flow in Alzheimer's disease
title The effect of physical exercise on cerebral blood flow in Alzheimer's disease
title_full The effect of physical exercise on cerebral blood flow in Alzheimer's disease
title_fullStr The effect of physical exercise on cerebral blood flow in Alzheimer's disease
title_full_unstemmed The effect of physical exercise on cerebral blood flow in Alzheimer's disease
title_short The effect of physical exercise on cerebral blood flow in Alzheimer's disease
title_sort effect of physical exercise on cerebral blood flow in alzheimer's disease
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129739/
https://www.ncbi.nlm.nih.gov/pubmed/30211001
http://dx.doi.org/10.1016/j.nicl.2018.09.003
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