Cargando…

Structural Basis for the Inhibition of Cyclin G‐Associated Kinase by Gefitinib

Gefitinib is the molecular target drug for advanced non‐small‐cell lung cancer. The primary target of gefitinib is the positive mutation of epidermal growth factor receptor, but it also inhibits cyclin G‐associated kinase (GAK). To reveal the molecular bases of GAK and gefitinib binding, structure a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ohbayashi, Naomi, Murayama, Kazutaka, Kato‐Murayama, Miyuki, Kukimoto‐Niino, Mutsuko, Uejima, Tamami, Matsuda, Takayoshi, Ohsawa, Noboru, Yokoyoma, Shigeyuki, Nojima, Hiroshi, Shirouzu, Mikako
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129943/ https://www.ncbi.nlm.nih.gov/pubmed/30214852 http://dx.doi.org/10.1002/open.201800177

Ejemplares similares

Cell-free synthesis of functional antibody fragments to provide a structural basis for antibody–antigen interaction
por: Matsuda, Takayoshi, et al.
Publicado: (2018)

Structural Insight into TNIK Inhibition
por: Kukimoto-Niino, Mutsuko, et al.
Publicado: (2022)

TNIK inhibition abrogates colorectal cancer stemness
por: Masuda, Mari, et al.
Publicado: (2016)

Cell-permeable Carboxyl-terminal p27(Kip1) Peptide Exhibits Anti-tumor Activity by Inhibiting Pim-1 Kinase
por: Morishita, Daisuke, et al.
Publicado: (2011)

A conserved PI(4,5)P2–binding domain is critical for immune regulatory function of DOCK8
por: Sakurai, Tetsuya, et al.
Publicado: (2021)

Lewis fucose is a key moiety for the recognition of histo‐blood group antigens by GI.9 norovirus, as revealed by structural analysis
por: Kimura‐Someya, Tomomi, et al.
Publicado: (2022)

Structural basis for disruption of claudin assembly in tight junctions by an enterotoxin
por: Shinoda, Takehiro, et al.
Publicado: (2016)

Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN
por: Shimizu, Kanako, et al.
Publicado: (2019)

Reduced efficacy of a Src kinase inhibitor in crowded protein solution
por: Kasahara, Kento, et al.
Publicado: (2021)

Direct homophilic interaction of LAMP2A with the two-domain architecture revealed by site-directed photo-crosslinks and steric hindrances in mammalian cells
por: Terasawa, Kazue, et al.
Publicado: (2021)

Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2
por: Shimizu, Kanako, et al.
Publicado: (2021)

Central catalytic domain of BRAP (RNF52) recognizes the types of ubiquitin chains and utilizes oligo-ubiquitin for ubiquitylation
por: Shoji, Shisako, et al.
Publicado: (2017)

Targeting Ras-binding domain of ELMO1 by computational nanobody design
por: Tam, Chunlai, et al.
Publicado: (2023)

Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex
por: Kukimoto-Niino, Mutsuko, et al.
Publicado: (2021)

Dimerization of DOCK2 Is Essential for DOCK2-Mediated Rac Activation and Lymphocyte Migration
por: Terasawa, Masao, et al.
Publicado: (2012)

The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylation
por: Shoji, Shisako, et al.
Publicado: (2014)

Biochemical and Biophysical Properties of Interactions between Subunits of the Peripheral Stalk Region of Human V-ATPase
por: Rahman, Suhaila, et al.
Publicado: (2013)

Structural basis for promoter specificity switching of RNA polymerase by a phage factor
por: Tagami, Shunsuke, et al.
Publicado: (2014)

Crystal structures of the S6K1 kinase domain in complexes with inhibitors
por: Niwa, Hideaki, et al.
Publicado: (2014)

Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell–cell adhesion
por: Shimizu, Hideaki, et al.
Publicado: (2017)

Protein stabilization utilizing a redefined codon
por: Ohtake, Kazumasa, et al.
Publicado: (2015)

Mutant LV(476-7)AA of A-subunit of Enterococcus hirae V(1)-ATPase: High affinity of A(3)B(3) complex to DF axis and low ATPase activity
por: Alam, Jahangir, et al.
Publicado: (2013)

Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1
por: Hirano, Rina, et al.
Publicado: (2022)

Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits
por: Shimizu, Hideaki, et al.
Publicado: (2016)

Loose Binding of the DF Axis with the A(3)B(3) Complex Stimulates the Initial Activity of Enterococcus hirae V(1)-ATPase
por: Alam, Md. Jahangir, et al.
Publicado: (2013)

Gefitinib and Luteolin Cause Growth Arrest of Human Prostate Cancer PC-3 Cells via Inhibition of Cyclin G-Associated Kinase and Induction of miR-630
por: Sakurai, Minami A., et al.
Publicado: (2014)

Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer
por: Mizuta, Hayato, et al.
Publicado: (2021)

Structural basis for heme detoxification by an ATP-binding cassette–type efflux pump in gram-positive pathogenic bacteria
por: Nakamura, Hiro, et al.
Publicado: (2022)

Structural basis for the sequence-specific RNA-recognition mechanism of human CUG-BP1 RRM3
por: Tsuda, Kengo, et al.
Publicado: (2009)

Proton beam therapy in non-small cell lung cancer: state of the art
por: Harada, Hideyuki, et al.
Publicado: (2017)

Cell-free methods to produce structurally intact mammalian membrane proteins
por: Shinoda, Takehiro, et al.
Publicado: (2016)

Topological Analysis of MAPK Cascade for Kinetic ErbB Signaling
por: Nakakuki, Takashi, et al.
Publicado: (2008)

Dictyostelium IQGAP-related Protein Specifically Involved in the Completion of Cytokinesis
por: Adachi, Hiroyuki, et al.
Publicado: (1997)

The anti‐human cytomegalovirus drug tricin inhibits cyclin‐dependent kinase 9
por: Sadanari, Hidetaka, et al.
Publicado: (2018)

Expression, purification, crystallization and preliminary X-ray diffraction analysis of galactokinase from Pyrococcus horikoshii. Erratum
por: Inagaki, Eiji, et al.
Publicado: (2006)

Structural basis for the dual RNA-recognition modes of human Tra2-β RRM
por: Tsuda, Kengo, et al.
Publicado: (2011)

Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation
por: Wakamori, Masatoshi, et al.
Publicado: (2015)

Investigating the Roles of the C-Terminal Domain of Plasmodium falciparum GyrA
por: Nagano, Soshichiro, et al.
Publicado: (2015)

Structural basis for CRMP2-induced axonal microtubule formation
por: Niwa, Shinsuke, et al.
Publicado: (2017)

Recent advances in understanding the molecular basis of melanogenesis in melanocytes
por: Ohbayashi, Norihiko, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_82s849sgch2d9ksov6pdkgu15s