Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis

Dysfunction of microglia, the brain’s immune cells, is linked to neurodegeneration. Homozygous missense mutations in TREM2 cause Nasu-Hakola disease (NHD), an early-onset dementia. To study the consequences of these TREM2 variants, we generated induced pluripotent stem cell-derived microglia-like ce...

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Detalles Bibliográficos
Autores principales: Garcia-Reitboeck, Pablo, Phillips, Alexandra, Piers, Thomas M., Villegas-Llerena, Claudio, Butler, Matt, Mallach, Anna, Rodrigues, Celia, Arber, Charles E., Heslegrave, Amanda, Zetterberg, Henrik, Neumann, Harald, Neame, Stephen, Houlden, Henry, Hardy, John, Pocock, Jennifer M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130048/
https://www.ncbi.nlm.nih.gov/pubmed/30157425
http://dx.doi.org/10.1016/j.celrep.2018.07.094

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