Cargando…

Outdoor work as a risk factor for high-grade cutaneous squamous cell carcinoma of the head and neck

INTRODUCTION: While it is clear that individuals with outdoor occupations are at a significantly greater risk of developing cutaneous squamous cell carcinoma (cSCC), no previous studies have investigated the potential association between the tumour grade and occupation in this patient population. AI...

Descripción completa

Detalles Bibliográficos
Autores principales: Szewczyk, Mateusz, Pazdrowski, Jakub, Golusiński, Paweł, Dańczak-Pazdrowska, Aleksandra, Pawlaczyk, Mariola, Sygut, Jacek, Marszałek, Andrzej, Golusiński, Wojciech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130134/
https://www.ncbi.nlm.nih.gov/pubmed/30206456
http://dx.doi.org/10.5114/ada.2018.75841
_version_ 1783353880746131456
author Szewczyk, Mateusz
Pazdrowski, Jakub
Golusiński, Paweł
Dańczak-Pazdrowska, Aleksandra
Pawlaczyk, Mariola
Sygut, Jacek
Marszałek, Andrzej
Golusiński, Wojciech
author_facet Szewczyk, Mateusz
Pazdrowski, Jakub
Golusiński, Paweł
Dańczak-Pazdrowska, Aleksandra
Pawlaczyk, Mariola
Sygut, Jacek
Marszałek, Andrzej
Golusiński, Wojciech
author_sort Szewczyk, Mateusz
collection PubMed
description INTRODUCTION: While it is clear that individuals with outdoor occupations are at a significantly greater risk of developing cutaneous squamous cell carcinoma (cSCC), no previous studies have investigated the potential association between the tumour grade and occupation in this patient population. AIM: To assess occupation as a risk factor for the development of high-grade cSCC. Secondarily, to determine the association between the tumour grade and other clinical characteristics. MATERIAL AND METHODS: Retrospective analysis of 256 patients treated for head and neck cSCC at our institution in 2007–2016. The following patient characteristics and variables were assessed: age; sex; tumour location and grade; profession; and education level. A univariate analysis was performed to assess the association between each study variable and grade 3 tumour differentiation. RESULTS: The following variables were significantly associated (p < 0.05) with grade 3 (G3) cSCC tumours: outdoor work vs. indoor work; primary school vs. high school education; and age. Additionally, patients with low-grade (G1) tumours were significantly younger (mean age: 72) than patients with high-grade (G3) tumours (mean age: 79) (p = 0.046). CONCLUSIONS: To our knowledge, this is the first study to assess the variables associated with the tumour grade among outdoor workers. These findings suggest that outdoor workers who develop cSCC are at a greater risk of developing more aggressive cancers. These findings provide additional support for classifying cSCC as an occupational disease. Early education about the dangers of sun exposure during the first years of school is essential to minimize the risks of developing high-grade skin cancer.
format Online
Article
Text
id pubmed-6130134
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Termedia Publishing House
record_format MEDLINE/PubMed
spelling pubmed-61301342018-09-11 Outdoor work as a risk factor for high-grade cutaneous squamous cell carcinoma of the head and neck Szewczyk, Mateusz Pazdrowski, Jakub Golusiński, Paweł Dańczak-Pazdrowska, Aleksandra Pawlaczyk, Mariola Sygut, Jacek Marszałek, Andrzej Golusiński, Wojciech Postepy Dermatol Alergol Original Paper INTRODUCTION: While it is clear that individuals with outdoor occupations are at a significantly greater risk of developing cutaneous squamous cell carcinoma (cSCC), no previous studies have investigated the potential association between the tumour grade and occupation in this patient population. AIM: To assess occupation as a risk factor for the development of high-grade cSCC. Secondarily, to determine the association between the tumour grade and other clinical characteristics. MATERIAL AND METHODS: Retrospective analysis of 256 patients treated for head and neck cSCC at our institution in 2007–2016. The following patient characteristics and variables were assessed: age; sex; tumour location and grade; profession; and education level. A univariate analysis was performed to assess the association between each study variable and grade 3 tumour differentiation. RESULTS: The following variables were significantly associated (p < 0.05) with grade 3 (G3) cSCC tumours: outdoor work vs. indoor work; primary school vs. high school education; and age. Additionally, patients with low-grade (G1) tumours were significantly younger (mean age: 72) than patients with high-grade (G3) tumours (mean age: 79) (p = 0.046). CONCLUSIONS: To our knowledge, this is the first study to assess the variables associated with the tumour grade among outdoor workers. These findings suggest that outdoor workers who develop cSCC are at a greater risk of developing more aggressive cancers. These findings provide additional support for classifying cSCC as an occupational disease. Early education about the dangers of sun exposure during the first years of school is essential to minimize the risks of developing high-grade skin cancer. Termedia Publishing House 2018-08-21 2018-08 /pmc/articles/PMC6130134/ /pubmed/30206456 http://dx.doi.org/10.5114/ada.2018.75841 Text en Copyright: © 2018 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Original Paper
Szewczyk, Mateusz
Pazdrowski, Jakub
Golusiński, Paweł
Dańczak-Pazdrowska, Aleksandra
Pawlaczyk, Mariola
Sygut, Jacek
Marszałek, Andrzej
Golusiński, Wojciech
Outdoor work as a risk factor for high-grade cutaneous squamous cell carcinoma of the head and neck
title Outdoor work as a risk factor for high-grade cutaneous squamous cell carcinoma of the head and neck
title_full Outdoor work as a risk factor for high-grade cutaneous squamous cell carcinoma of the head and neck
title_fullStr Outdoor work as a risk factor for high-grade cutaneous squamous cell carcinoma of the head and neck
title_full_unstemmed Outdoor work as a risk factor for high-grade cutaneous squamous cell carcinoma of the head and neck
title_short Outdoor work as a risk factor for high-grade cutaneous squamous cell carcinoma of the head and neck
title_sort outdoor work as a risk factor for high-grade cutaneous squamous cell carcinoma of the head and neck
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130134/
https://www.ncbi.nlm.nih.gov/pubmed/30206456
http://dx.doi.org/10.5114/ada.2018.75841
work_keys_str_mv AT szewczykmateusz outdoorworkasariskfactorforhighgradecutaneoussquamouscellcarcinomaoftheheadandneck
AT pazdrowskijakub outdoorworkasariskfactorforhighgradecutaneoussquamouscellcarcinomaoftheheadandneck
AT golusinskipaweł outdoorworkasariskfactorforhighgradecutaneoussquamouscellcarcinomaoftheheadandneck
AT danczakpazdrowskaaleksandra outdoorworkasariskfactorforhighgradecutaneoussquamouscellcarcinomaoftheheadandneck
AT pawlaczykmariola outdoorworkasariskfactorforhighgradecutaneoussquamouscellcarcinomaoftheheadandneck
AT sygutjacek outdoorworkasariskfactorforhighgradecutaneoussquamouscellcarcinomaoftheheadandneck
AT marszałekandrzej outdoorworkasariskfactorforhighgradecutaneoussquamouscellcarcinomaoftheheadandneck
AT golusinskiwojciech outdoorworkasariskfactorforhighgradecutaneoussquamouscellcarcinomaoftheheadandneck