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An overview of the synergy and crosstalk between pentraxins and collectins/ficolins: their functional relevance in complement activation
The complement system is an innate immune defense machinery comprising components that deploy rapid immune responses and provide efficient protection against foreign invaders and unwanted host elements. The complement system is activated upon recognition of pathogenic microorganisms or altered self-...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130212/ https://www.ncbi.nlm.nih.gov/pubmed/28428631 http://dx.doi.org/10.1038/emm.2017.51 |
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author | Ma, Ying Jie Lee, Bok Luel Garred, Peter |
author_facet | Ma, Ying Jie Lee, Bok Luel Garred, Peter |
author_sort | Ma, Ying Jie |
collection | PubMed |
description | The complement system is an innate immune defense machinery comprising components that deploy rapid immune responses and provide efficient protection against foreign invaders and unwanted host elements. The complement system is activated upon recognition of pathogenic microorganisms or altered self-cells by exclusive pattern recognition molecules (PRMs), such as collectins, ficolins and pentraxins. Recent accumulating evidence shows that the different classes of effector PRMs build up a co-operative network and exert synergistic effects on complement activation. In this review, we describe our updated view of the crosstalk between previously unlinked PRMs in complement activation and the potential pathogenic effects during infection and inflammation. |
format | Online Article Text |
id | pubmed-6130212 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-61302122018-09-12 An overview of the synergy and crosstalk between pentraxins and collectins/ficolins: their functional relevance in complement activation Ma, Ying Jie Lee, Bok Luel Garred, Peter Exp Mol Med Review The complement system is an innate immune defense machinery comprising components that deploy rapid immune responses and provide efficient protection against foreign invaders and unwanted host elements. The complement system is activated upon recognition of pathogenic microorganisms or altered self-cells by exclusive pattern recognition molecules (PRMs), such as collectins, ficolins and pentraxins. Recent accumulating evidence shows that the different classes of effector PRMs build up a co-operative network and exert synergistic effects on complement activation. In this review, we describe our updated view of the crosstalk between previously unlinked PRMs in complement activation and the potential pathogenic effects during infection and inflammation. Nature Publishing Group 2017-04 2017-04-21 /pmc/articles/PMC6130212/ /pubmed/28428631 http://dx.doi.org/10.1038/emm.2017.51 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ |
spellingShingle | Review Ma, Ying Jie Lee, Bok Luel Garred, Peter An overview of the synergy and crosstalk between pentraxins and collectins/ficolins: their functional relevance in complement activation |
title | An overview of the synergy and crosstalk between pentraxins and collectins/ficolins: their functional relevance in complement activation |
title_full | An overview of the synergy and crosstalk between pentraxins and collectins/ficolins: their functional relevance in complement activation |
title_fullStr | An overview of the synergy and crosstalk between pentraxins and collectins/ficolins: their functional relevance in complement activation |
title_full_unstemmed | An overview of the synergy and crosstalk between pentraxins and collectins/ficolins: their functional relevance in complement activation |
title_short | An overview of the synergy and crosstalk between pentraxins and collectins/ficolins: their functional relevance in complement activation |
title_sort | overview of the synergy and crosstalk between pentraxins and collectins/ficolins: their functional relevance in complement activation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130212/ https://www.ncbi.nlm.nih.gov/pubmed/28428631 http://dx.doi.org/10.1038/emm.2017.51 |
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