Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators

Transcriptional coactivators are a molecular recognition marvel because a single domain within these proteins, the activator binding domain or ABD, interacts with multiple compositionally diverse transcriptional activators. Also remarkable is the structural diversity among ABDs, which range from con...

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Detalles Bibliográficos
Autores principales: Henderson, Andrew R., Henley, Matthew J., Foster, Nicholas J., Peiffer, Amanda L., Beyersdorf, Matthew S., Stanford, Kevon D., Sturlis, Steven M., Linhares, Brian M., Hill, Zachary B., Wells, James A., Cierpicki, Tomasz, Brooks, Charles L., Fierke, Carol A., Mapp, Anna K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130367/
https://www.ncbi.nlm.nih.gov/pubmed/30127017
http://dx.doi.org/10.1073/pnas.1806202115

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