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Comparative effects of green and black tea extracts on lowering serum uric acid in hyperuricemic mice
Context: Tea (Camellia sinensis (L.) Kuntze [Theaceae]) is used to induce urination and inducing nervous excitation. Green and black teas have multifarious physiological functions. The different effects of green and black tea aqueous extracts (GTEs and BTEs) on hyperuricemia are not definitely repor...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130494/ https://www.ncbi.nlm.nih.gov/pubmed/28938867 http://dx.doi.org/10.1080/13880209.2017.1377736 |
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author | Zhu, Chuang Tai, Ling-Ling Wan, Xiao-chun Li, Da-xiang Zhao, Yong-Qing Xu, Yan |
author_facet | Zhu, Chuang Tai, Ling-Ling Wan, Xiao-chun Li, Da-xiang Zhao, Yong-Qing Xu, Yan |
author_sort | Zhu, Chuang |
collection | PubMed |
description | Context: Tea (Camellia sinensis (L.) Kuntze [Theaceae]) is used to induce urination and inducing nervous excitation. Green and black teas have multifarious physiological functions. The different effects of green and black tea aqueous extracts (GTEs and BTEs) on hyperuricemia are not definitely reported. Objective: The different effects of GTEs and BTEs on lowering serum uric acid (UA) in hyperuricemic mice were determined. Materials and methods: Kunming mice were divided into nine groups (n = 6/each group). GTEs and BTEs at the doses of 0.5, 1 and 2 g/kg were orally administrated to mice for seven days, respectively. Hepatic xanthine oxidase (XOD) and adenosine deaminase (ADA) activities as mechanisms of actions were assessed. Results: Research indicated that the LD(50) of tea extract is greater than 2 g/kg in mice. UA levels were suppressed significantly with dose-dependent treatment of 0.5, 1 and 2 g/kg BTEs (up to 25.5%, 28.7% and 29.8%, respectively); the serum UA levels were decreased by GTEs but not significant. The activities of XOD and ADA in high dose (2 g/kg) groups of both GTEs and BTEs were notably lower than those of the model group. Discussion and conclusions: The results suggested that both GTEs and BTEs have hypouricaemic and renal protective effects on hyperuricemic mice and the latter one was better. Our study sheds light on the research and development of anti-hyperuricemic functional foods and drugs from tea. |
format | Online Article Text |
id | pubmed-6130494 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-61304942018-09-27 Comparative effects of green and black tea extracts on lowering serum uric acid in hyperuricemic mice Zhu, Chuang Tai, Ling-Ling Wan, Xiao-chun Li, Da-xiang Zhao, Yong-Qing Xu, Yan Pharm Biol Research Article Context: Tea (Camellia sinensis (L.) Kuntze [Theaceae]) is used to induce urination and inducing nervous excitation. Green and black teas have multifarious physiological functions. The different effects of green and black tea aqueous extracts (GTEs and BTEs) on hyperuricemia are not definitely reported. Objective: The different effects of GTEs and BTEs on lowering serum uric acid (UA) in hyperuricemic mice were determined. Materials and methods: Kunming mice were divided into nine groups (n = 6/each group). GTEs and BTEs at the doses of 0.5, 1 and 2 g/kg were orally administrated to mice for seven days, respectively. Hepatic xanthine oxidase (XOD) and adenosine deaminase (ADA) activities as mechanisms of actions were assessed. Results: Research indicated that the LD(50) of tea extract is greater than 2 g/kg in mice. UA levels were suppressed significantly with dose-dependent treatment of 0.5, 1 and 2 g/kg BTEs (up to 25.5%, 28.7% and 29.8%, respectively); the serum UA levels were decreased by GTEs but not significant. The activities of XOD and ADA in high dose (2 g/kg) groups of both GTEs and BTEs were notably lower than those of the model group. Discussion and conclusions: The results suggested that both GTEs and BTEs have hypouricaemic and renal protective effects on hyperuricemic mice and the latter one was better. Our study sheds light on the research and development of anti-hyperuricemic functional foods and drugs from tea. Taylor & Francis 2017-09-22 /pmc/articles/PMC6130494/ /pubmed/28938867 http://dx.doi.org/10.1080/13880209.2017.1377736 Text en © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhu, Chuang Tai, Ling-Ling Wan, Xiao-chun Li, Da-xiang Zhao, Yong-Qing Xu, Yan Comparative effects of green and black tea extracts on lowering serum uric acid in hyperuricemic mice |
title | Comparative effects of green and black tea extracts on lowering serum uric acid in hyperuricemic mice |
title_full | Comparative effects of green and black tea extracts on lowering serum uric acid in hyperuricemic mice |
title_fullStr | Comparative effects of green and black tea extracts on lowering serum uric acid in hyperuricemic mice |
title_full_unstemmed | Comparative effects of green and black tea extracts on lowering serum uric acid in hyperuricemic mice |
title_short | Comparative effects of green and black tea extracts on lowering serum uric acid in hyperuricemic mice |
title_sort | comparative effects of green and black tea extracts on lowering serum uric acid in hyperuricemic mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130494/ https://www.ncbi.nlm.nih.gov/pubmed/28938867 http://dx.doi.org/10.1080/13880209.2017.1377736 |
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