Relatedness disequilibrium regression estimates heritability without environmental bias

Heritability measures the proportion of trait variation that is due to genetic inheritance. Measurement of heritability is of importance to the nature-versus-nurture debate. However, existing estimates of heritability could be biased by environmental effects. Here we introduce relatedness disequilib...

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Autores principales: Young, Alexander I., Frigge, Michael L., Gudbjartsson, Daniel F., Thorleifsson, Gudmar, Bjornsdottir, Gyda, Sulem, Patrick, Masson, Gisli, Thorsteinsdottir, Unnur, Stefansson, Kari, Kong, Augustine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130754/
https://www.ncbi.nlm.nih.gov/pubmed/30104764
http://dx.doi.org/10.1038/s41588-018-0178-9
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author Young, Alexander I.
Frigge, Michael L.
Gudbjartsson, Daniel F.
Thorleifsson, Gudmar
Bjornsdottir, Gyda
Sulem, Patrick
Masson, Gisli
Thorsteinsdottir, Unnur
Stefansson, Kari
Kong, Augustine
author_facet Young, Alexander I.
Frigge, Michael L.
Gudbjartsson, Daniel F.
Thorleifsson, Gudmar
Bjornsdottir, Gyda
Sulem, Patrick
Masson, Gisli
Thorsteinsdottir, Unnur
Stefansson, Kari
Kong, Augustine
author_sort Young, Alexander I.
collection PubMed
description Heritability measures the proportion of trait variation that is due to genetic inheritance. Measurement of heritability is of importance to the nature-versus-nurture debate. However, existing estimates of heritability could be biased by environmental effects. Here we introduce relatedness disequilibrium regression (RDR), a novel method for estimating heritability. RDR avoids most sources of environmental bias by exploiting variation in relatedness due to random Mendelian segregation. We use a sample of 54,888 Icelanders with both parents genotyped to estimate the heritability of 14 traits, including height (55.4%, S.E. 4.4%) and educational attainment (17.0%, S.E. 9.4%). Our results suggest that some other estimates of heritability could be inflated by environmental effects.
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spelling pubmed-61307542019-02-13 Relatedness disequilibrium regression estimates heritability without environmental bias Young, Alexander I. Frigge, Michael L. Gudbjartsson, Daniel F. Thorleifsson, Gudmar Bjornsdottir, Gyda Sulem, Patrick Masson, Gisli Thorsteinsdottir, Unnur Stefansson, Kari Kong, Augustine Nat Genet Article Heritability measures the proportion of trait variation that is due to genetic inheritance. Measurement of heritability is of importance to the nature-versus-nurture debate. However, existing estimates of heritability could be biased by environmental effects. Here we introduce relatedness disequilibrium regression (RDR), a novel method for estimating heritability. RDR avoids most sources of environmental bias by exploiting variation in relatedness due to random Mendelian segregation. We use a sample of 54,888 Icelanders with both parents genotyped to estimate the heritability of 14 traits, including height (55.4%, S.E. 4.4%) and educational attainment (17.0%, S.E. 9.4%). Our results suggest that some other estimates of heritability could be inflated by environmental effects. 2018-08-13 2018-09 /pmc/articles/PMC6130754/ /pubmed/30104764 http://dx.doi.org/10.1038/s41588-018-0178-9 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Young, Alexander I.
Frigge, Michael L.
Gudbjartsson, Daniel F.
Thorleifsson, Gudmar
Bjornsdottir, Gyda
Sulem, Patrick
Masson, Gisli
Thorsteinsdottir, Unnur
Stefansson, Kari
Kong, Augustine
Relatedness disequilibrium regression estimates heritability without environmental bias
title Relatedness disequilibrium regression estimates heritability without environmental bias
title_full Relatedness disequilibrium regression estimates heritability without environmental bias
title_fullStr Relatedness disequilibrium regression estimates heritability without environmental bias
title_full_unstemmed Relatedness disequilibrium regression estimates heritability without environmental bias
title_short Relatedness disequilibrium regression estimates heritability without environmental bias
title_sort relatedness disequilibrium regression estimates heritability without environmental bias
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130754/
https://www.ncbi.nlm.nih.gov/pubmed/30104764
http://dx.doi.org/10.1038/s41588-018-0178-9
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