Indolyl-Pyridinyl-Propenone-Induced Methuosis through the Inhibition of PIKFYVE

[Image: see text] Methuosis is a form of nonapoptotic cell death characterized by the accumulation of macropinosome-derived vacuoles. Herein, we identify PIKFYVE, a class III phosphoinositide (PI) kinase, as the protein target responsible for the methuosis-inducing activity of indolyl-pyridinyl-prop...

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Detalles Bibliográficos
Autores principales: Cho, Hyelim, Geno, Erin, Patoor, Maude, Reid, Adam, McDonald, Rick, Hild, Marc, Jenkins, Jeremy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130785/
https://www.ncbi.nlm.nih.gov/pubmed/30221232
http://dx.doi.org/10.1021/acsomega.8b00202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130785/
https://www.ncbi.nlm.nih.gov/pubmed/30221232
http://dx.doi.org/10.1021/acsomega.8b00202

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