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Highly Potent, Stable, and Selective Dimeric Hetarylpropylguanidine-Type Histamine H(2) Receptor Agonists†

[Image: see text] On the basis of the long-known prototypic pharmacophore 3-(1H-imidazol-4-yl)propylguanidine (SK&F 91486, 2), monomeric, homodimeric, and heterodimeric bisalkylguanidine-type histamine H(2) receptor (H(2)R) agonists with various alkyl spacers were synthesized. Aiming at increase...

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Detalles Bibliográficos
Autores principales:	Pockes, Steffen, Wifling, David, Keller, Max, Buschauer, Armin, Elz, Sigurd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130797/ https://www.ncbi.nlm.nih.gov/pubmed/30221224 http://dx.doi.org/10.1021/acsomega.8b00128

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