eIF4E phosphorylation regulates ongoing pain, independently of inflammation, and hyperalgesic priming in the mouse CFA model

Mitogen activated protein kinase-interacting kinase (MNK)-mediated phosphorylation of the mRNA cap binding protein eIF4E controls the translation of a subset of mRNAs that are involved in neuronal and immune plasticity. MNK-eIF4E signaling plays a crucial role in the response of nociceptors to injur...

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Detalles Bibliográficos
Autores principales: Moy, Jamie K., Kuhn, Jasper L., Szabo-Pardi, Thomas A., Pradhan, Grishma, Price, Theodore J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130839/
https://www.ncbi.nlm.nih.gov/pubmed/30211343
http://dx.doi.org/10.1016/j.ynpai.2018.03.001

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