Terminal uridylyltransferases target RNA viruses as part of the innate immune system

RNA viruses are a major threat to animals and plants. RNA interference (RNAi) and the interferon response provide innate antiviral defense against RNA viruses. Here we performed a large-scale screen using C. elegans and its natural pathogen, the Orsay virus (OrV), and identified cde-1 as important f...

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Detalles Bibliográficos
Autores principales: Le Pen, Jérémie, Jiang, Hongbing, Di Domenico, Tomás, Kneuss, Emma, Kosałka, Joanna, Leung, Christian, Morgan, Marcos, Much, Christian, Rudolph, Konrad L. M., Enright, Anton J., O’Carroll, Dónal, Wang, David, Miska, Eric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130846/
https://www.ncbi.nlm.nih.gov/pubmed/30104661
http://dx.doi.org/10.1038/s41594-018-0106-9

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