Cytochrome P450 and O-methyltransferase catalyze the final steps in the biosynthesis of the anti-addictive alkaloid ibogaine from Tabernanthe iboga

Monoterpenoid indole alkaloids are a large (∼3000 members) and structurally diverse class of metabolites restricted to a limited number of plant families in the order Gentianales. Tabernanthe iboga or iboga (Apocynaceae) is native to western equatorial Africa and has been used in traditional medicin...

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Detalles Bibliográficos
Autores principales: Farrow, Scott C., Kamileen, Mohamed O., Meades, Jessica, Ameyaw, Belinda, Xiao, Youli, O'Connor, Sarah E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Plant Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130943/
https://www.ncbi.nlm.nih.gov/pubmed/30030374
http://dx.doi.org/10.1074/jbc.RA118.004060

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