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TMPRSS11A activates the influenza A virus hemagglutinin and the MERS coronavirus spike protein and is insensitive against blockade by HAI-1

The influenza virus hemagglutinin (HA) facilitates viral entry into target cells. Cleavage of HA by host cell proteases is essential for viral infectivity, and the responsible enzymes are potential targets for antiviral intervention. The type II transmembrane serine protease (TTSP) TMPRSS2 has been...

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Detalles Bibliográficos
Autores principales:	Zmora, Pawel, Hoffmann, Markus, Kollmus, Heike, Moldenhauer, Anna-Sophie, Danov, Olga, Braun, Armin, Winkler, Michael, Schughart, Klaus, Pöhlmann, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2018
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130959/ https://www.ncbi.nlm.nih.gov/pubmed/29976755 http://dx.doi.org/10.1074/jbc.RA118.001273

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