Cargando…

NSF-mediated disassembly of on- and off-pathway SNARE complexes and inhibition by complexin

SNARE complex disassembly by the ATPase NSF is essential for neurotransmitter release and other membrane trafficking processes. We developed a single-molecule FRET assay to monitor repeated rounds of NSF-mediated disassembly and reassembly of individual SNARE complexes. For ternary neuronal SNARE co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Choi, Ucheor B, Zhao, Minglei, White, K Ian, Pfuetzner, Richard A, Esquivies, Luis, Zhou, Qiangjun, Brunger, Axel T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Microbiology and Infectious Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130971/ https://www.ncbi.nlm.nih.gov/pubmed/29985126 http://dx.doi.org/10.7554/eLife.36497

Ejemplares similares

Structural principles of SNARE complex recognition by the AAA+ protein NSF
por: White, K Ian, et al.
Publicado: (2018)

Analysis of tripartite Synaptotagmin‐1‐SNARE‐complexin‐1 complexes in solution
por: Jaczynska, Klaudia, et al.
Publicado: (2022)

Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complex
por: Choi, Ucheor B, et al.
Publicado: (2016)

Complexin-1 Enhances the On-Rate of Vesicle Docking via Simultaneous SNARE and Membrane Interactions
por: Diao, Jiajie, et al.
Publicado: (2013)

Munc18a Does Not Alter Fusion Rates Mediated by Neuronal SNAREs, Synaptotagmin, and Complexin
por: Zhang, Yunxiang, et al.
Publicado: (2015)

Disassembly of All SNARE Complexes by N-Ethylmaleimide-sensitive Factor (NSF) Is Initiated by a Conserved 1:1 Interaction between α-Soluble NSF Attachment Protein (SNAP) and SNARE Complex
por: Vivona, Sandro, et al.
Publicado: (2013)

Sensory deficit screen identifies nsf mutation that differentially affects SNARE recycling and quality control
por: Gao, Yan, et al.
Publicado: (2023)

Stimulation of NSF ATPase Activity by α-SNAP Is Required for SNARE Complex Disassembly and Exocytosis
por: Barnard, Richard J.O., et al.
Publicado: (1997)

Structures of neurexophilin–neurexin complexes reveal a regulatory mechanism of alternative splicing
por: Wilson, Steven C, et al.
Publicado: (2019)

Mechanistic insights into the recycling machine of the SNARE complex
por: Zhao, Minglei, et al.
Publicado: (2015)

Architecture of the Synaptotagmin-SNARE Machinery for Neuronal Exocytosis
por: Zhou, Qiangjun, et al.
Publicado: (2015)

Processive ATP-driven Substrate Disassembly by the N-Ethylmaleimide-sensitive Factor (NSF) Molecular Machine
por: Cipriano, Daniel J., et al.
Publicado: (2013)

Concurrent Binding of Complexin and Synaptotagmin to Liposome-Embedded SNARE Complexes
por: Chicka, Michael C., et al.
Publicado: (2009)

Structural conservation among variants of the SARS-CoV-2 spike postfusion bundle
por: Yang, Kailu, et al.
Publicado: (2022)

Cell Types and Synapses Expressing the SNARE Complex Regulating Proteins Complexin 1 and Complexin 2 in Mammalian Retina
por: Lux, Uwe Thorsten, et al.
Publicado: (2021)

Complexin inhibits spontaneous release and synchronizes Ca(2+)-triggered synaptic vesicle fusion by distinct mechanisms
por: Lai, Ying, et al.
Publicado: (2014)

The Accessory Helix of Complexin Stabilizes a Partially Unzippered State of the SNARE Complex and Mediates the Complexin Clamping Function In Vivo
por: Brady, Joshua, et al.
Publicado: (2021)

Single-molecule FRET-derived model of the synaptotagmin 1–SNARE fusion complex
por: Choi, Ucheor B., et al.
Publicado: (2010)

Sequential SNARE disassembly and GATE-16–GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion
por: Müller, Joyce M.M., et al.
Publicado: (2002)

The pre-synaptic fusion machinery
por: Brunger, Axel T, et al.
Publicado: (2019)

Mechanistic insights into the SNARE complex disassembly
por: Huang, Xuan, et al.
Publicado: (2019)

Complexin and Ca(2+) stimulate SNARE-mediated membrane fusion
por: Yoon, Tae-Young, et al.
Publicado: (2008)

LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate
por: Belluzzi, Elisa, et al.
Publicado: (2016)

Reconciling isothermal titration calorimetry analyses of interactions between complexin and truncated SNARE complexes
por: Prinslow, Eric A, et al.
Publicado: (2017)

Structure-based design of a SARS-CoV-2 Omicron-specific inhibitor
por: Yang, Kailu, et al.
Publicado: (2023)

Stabilization of the SNARE Core by Complexin-1 Facilitates Fusion Pore Expansion
por: Pierson, Josh, et al.
Publicado: (2021)

Complexin cross-links pre-fusion SNAREs into a zig-zag array: a structure-based model for complexin clamping
por: Kümmel, Daniel, et al.
Publicado: (2011)

Focused clamping of a single neuronal SNARE complex by complexin under high mechanical tension
por: Shon, Min Ju, et al.
Publicado: (2018)

Multiple factors maintain assembled trans-SNARE complexes in the presence of NSF and αSNAP
por: Prinslow, Eric A, et al.
Publicado: (2019)

Screening of Hydrocarbon-Stapled Peptides for Inhibition of Calcium-Triggered Exocytosis
por: Lai, Ying, et al.
Publicado: (2022)

Complexin-1 regulated assembly of single neuronal SNARE complex revealed by single-molecule optical tweezers
por: Hao, Tongrui, et al.
Publicado: (2023)

Involvement of Complexin 2 in Docking, Locking and Unlocking of Different SNARE Complexes during Sperm Capacitation and Induced Acrosomal Exocytosis
por: Tsai, Pei-Shiue J., et al.
Publicado: (2012)

Lysophosphatidylcholine inhibits membrane-associated SNARE complex disassembly
por: Shin, Leah, et al.
Publicado: (2012)

Advances in X-ray free electron laser (XFEL) diffraction data processing applied to the crystal structure of the synaptotagmin-1 / SNARE complex
por: Lyubimov, Artem Y, et al.
Publicado: (2016)

Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion
por: Malmersjö, Seth, et al.
Publicado: (2016)

The alternative sigma factor σ(X) mediates competence shut-off at the cell pole in Streptococcus pneumoniae
por: Johnston, Calum HG, et al.
Publicado: (2020)

Stem cell heterogeneity drives the parasitic life cycle of Schistosoma mansoni
por: Wang, Bo, et al.
Publicado: (2018)

Use of Off-Label Drugs in COVID-19: Clinicians’ Perceptions Based on a Cross-Sectional Observational Study
por: Sagar, Anubha, et al.
Publicado: (2023)

All-atom molecular dynamics simulations of Synaptotagmin-SNARE-complexin complexes bridging a vesicle and a flat lipid bilayer
por: Rizo, Josep, et al.
Publicado: (2022)

Inhibition of calcium-triggered secretion by hydrocarbon-stapled peptides
por: Lai, Ying, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8th0aq0flqq82nelna0nupps6s