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Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut
Ploidy-increasing cell cycles drive tissue growth in many developing organs. Such cycles, including endocycles, are increasingly appreciated to drive tissue growth following injury or activated growth signaling in mature organs. In these organs, the regulation and distinct roles of different cell cy...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130973/ https://www.ncbi.nlm.nih.gov/pubmed/30117808 http://dx.doi.org/10.7554/eLife.38327 |
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author | Cohen, Erez Allen, Scott R Sawyer, Jessica K Fox, Donald T |
author_facet | Cohen, Erez Allen, Scott R Sawyer, Jessica K Fox, Donald T |
author_sort | Cohen, Erez |
collection | PubMed |
description | Ploidy-increasing cell cycles drive tissue growth in many developing organs. Such cycles, including endocycles, are increasingly appreciated to drive tissue growth following injury or activated growth signaling in mature organs. In these organs, the regulation and distinct roles of different cell cycles remains unclear. Here, we uncover a programmed switch between cell cycles in the Drosophila hindgut pylorus. Using an acute injury model, we identify mitosis as the response in larval pyloric cells, whereas endocycles occur in adult pyloric cells. By developing a novel genetic method, DEMISE (Dual-Expression-Method-for-Induced-Site-specific-Eradication), we show the cell cycle regulator Fizzy-related dictates the decision between mitosis and endocycles. After injury, both cycles accurately restore tissue mass and genome content. However, in response to sustained growth signaling, only endocycles preserve epithelial architecture. Our data reveal distinct cell cycle programming in response to similar stimuli in mature vs. developmental states and reveal a tissue-protective role of endocycles. |
format | Online Article Text |
id | pubmed-6130973 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-61309732018-09-12 Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut Cohen, Erez Allen, Scott R Sawyer, Jessica K Fox, Donald T eLife Developmental Biology Ploidy-increasing cell cycles drive tissue growth in many developing organs. Such cycles, including endocycles, are increasingly appreciated to drive tissue growth following injury or activated growth signaling in mature organs. In these organs, the regulation and distinct roles of different cell cycles remains unclear. Here, we uncover a programmed switch between cell cycles in the Drosophila hindgut pylorus. Using an acute injury model, we identify mitosis as the response in larval pyloric cells, whereas endocycles occur in adult pyloric cells. By developing a novel genetic method, DEMISE (Dual-Expression-Method-for-Induced-Site-specific-Eradication), we show the cell cycle regulator Fizzy-related dictates the decision between mitosis and endocycles. After injury, both cycles accurately restore tissue mass and genome content. However, in response to sustained growth signaling, only endocycles preserve epithelial architecture. Our data reveal distinct cell cycle programming in response to similar stimuli in mature vs. developmental states and reveal a tissue-protective role of endocycles. eLife Sciences Publications, Ltd 2018-08-17 /pmc/articles/PMC6130973/ /pubmed/30117808 http://dx.doi.org/10.7554/eLife.38327 Text en © 2018, Cohen et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Developmental Biology Cohen, Erez Allen, Scott R Sawyer, Jessica K Fox, Donald T Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut |
title | Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut |
title_full | Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut |
title_fullStr | Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut |
title_full_unstemmed | Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut |
title_short | Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut |
title_sort | fizzy-related dictates a cell cycle switch during organ repair and tissue growth responses in the drosophila hindgut |
topic | Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130973/ https://www.ncbi.nlm.nih.gov/pubmed/30117808 http://dx.doi.org/10.7554/eLife.38327 |
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