Cargando…
Cocaine- and Amphetamine-Regulated Transcript (CART) Peptide Plays Critical Role in Psychostimulant-Induced Depression
Cocaine- and amphetamine-regulated transcript (CART) peptide is a widely distributed neurotransmitter expressed in the central nervous systems. Previously, several reports demonstrated that nucleus accumbal-injected CART peptide positively modulated behavioral sensitization induced by psychostimulan...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Applied Pharmacology
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131014/ https://www.ncbi.nlm.nih.gov/pubmed/30157614 http://dx.doi.org/10.4062/biomolther.2018.141 |
_version_ | 1783354034601590784 |
---|---|
author | Meng, Qing Kim, Hyoung-Chun Oh, Seikwan Lee, Yong-Moon Hu, Zhenzhen Oh, Ki-Wan |
author_facet | Meng, Qing Kim, Hyoung-Chun Oh, Seikwan Lee, Yong-Moon Hu, Zhenzhen Oh, Ki-Wan |
author_sort | Meng, Qing |
collection | PubMed |
description | Cocaine- and amphetamine-regulated transcript (CART) peptide is a widely distributed neurotransmitter expressed in the central nervous systems. Previously, several reports demonstrated that nucleus accumbal-injected CART peptide positively modulated behavioral sensitization induced by psychostimulants and regulated the mesocorticolimbic dopaminergic pathway. It is confirmed that CART peptide exerted inhibitory effect on psychostimulant-enhanced dopamine receptors signaling, Ca(2+)/calmodulin-dependent kinase signaling and crucial transcription factors expression. Besides modulation of dopamine receptors-related pathways, CART peptide also exhibited elaborated interactions with other neurotransmitter receptors, such as glutamate receptors and γ-aminobutyric acid receptors, which further account for attribution of CART peptide to inhibition of psychostimulant-potentiated locomotor activity. Recently, CART peptide has been shown to have anxiolytic functions on the aversive mood and uncontrolled drug-seeking behaviors following drug withdrawal. Moreover, microinjection of CART peptide has been shown to have an anti-depressant effect, which suggests its potential utility in the mood regulation and avoidance of depression-like behaviors. In this review, we discuss CART pathways in neural circuits and their interactions with neurotransmitters associated with psychostimulant-induced depression. |
format | Online Article Text |
id | pubmed-6131014 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Korean Society of Applied Pharmacology |
record_format | MEDLINE/PubMed |
spelling | pubmed-61310142018-09-12 Cocaine- and Amphetamine-Regulated Transcript (CART) Peptide Plays Critical Role in Psychostimulant-Induced Depression Meng, Qing Kim, Hyoung-Chun Oh, Seikwan Lee, Yong-Moon Hu, Zhenzhen Oh, Ki-Wan Biomol Ther (Seoul) Invited Review Cocaine- and amphetamine-regulated transcript (CART) peptide is a widely distributed neurotransmitter expressed in the central nervous systems. Previously, several reports demonstrated that nucleus accumbal-injected CART peptide positively modulated behavioral sensitization induced by psychostimulants and regulated the mesocorticolimbic dopaminergic pathway. It is confirmed that CART peptide exerted inhibitory effect on psychostimulant-enhanced dopamine receptors signaling, Ca(2+)/calmodulin-dependent kinase signaling and crucial transcription factors expression. Besides modulation of dopamine receptors-related pathways, CART peptide also exhibited elaborated interactions with other neurotransmitter receptors, such as glutamate receptors and γ-aminobutyric acid receptors, which further account for attribution of CART peptide to inhibition of psychostimulant-potentiated locomotor activity. Recently, CART peptide has been shown to have anxiolytic functions on the aversive mood and uncontrolled drug-seeking behaviors following drug withdrawal. Moreover, microinjection of CART peptide has been shown to have an anti-depressant effect, which suggests its potential utility in the mood regulation and avoidance of depression-like behaviors. In this review, we discuss CART pathways in neural circuits and their interactions with neurotransmitters associated with psychostimulant-induced depression. The Korean Society of Applied Pharmacology 2018-09 2018-09-01 /pmc/articles/PMC6131014/ /pubmed/30157614 http://dx.doi.org/10.4062/biomolther.2018.141 Text en Copyright ©2018, The Korean Society of Applied Pharmacology http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Invited Review Meng, Qing Kim, Hyoung-Chun Oh, Seikwan Lee, Yong-Moon Hu, Zhenzhen Oh, Ki-Wan Cocaine- and Amphetamine-Regulated Transcript (CART) Peptide Plays Critical Role in Psychostimulant-Induced Depression |
title | Cocaine- and Amphetamine-Regulated Transcript (CART) Peptide Plays Critical Role in Psychostimulant-Induced Depression |
title_full | Cocaine- and Amphetamine-Regulated Transcript (CART) Peptide Plays Critical Role in Psychostimulant-Induced Depression |
title_fullStr | Cocaine- and Amphetamine-Regulated Transcript (CART) Peptide Plays Critical Role in Psychostimulant-Induced Depression |
title_full_unstemmed | Cocaine- and Amphetamine-Regulated Transcript (CART) Peptide Plays Critical Role in Psychostimulant-Induced Depression |
title_short | Cocaine- and Amphetamine-Regulated Transcript (CART) Peptide Plays Critical Role in Psychostimulant-Induced Depression |
title_sort | cocaine- and amphetamine-regulated transcript (cart) peptide plays critical role in psychostimulant-induced depression |
topic | Invited Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131014/ https://www.ncbi.nlm.nih.gov/pubmed/30157614 http://dx.doi.org/10.4062/biomolther.2018.141 |
work_keys_str_mv | AT mengqing cocaineandamphetamineregulatedtranscriptcartpeptideplayscriticalroleinpsychostimulantinduceddepression AT kimhyoungchun cocaineandamphetamineregulatedtranscriptcartpeptideplayscriticalroleinpsychostimulantinduceddepression AT ohseikwan cocaineandamphetamineregulatedtranscriptcartpeptideplayscriticalroleinpsychostimulantinduceddepression AT leeyongmoon cocaineandamphetamineregulatedtranscriptcartpeptideplayscriticalroleinpsychostimulantinduceddepression AT huzhenzhen cocaineandamphetamineregulatedtranscriptcartpeptideplayscriticalroleinpsychostimulantinduceddepression AT ohkiwan cocaineandamphetamineregulatedtranscriptcartpeptideplayscriticalroleinpsychostimulantinduceddepression |