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Distribution of Antisense Oligonucleotides in Rat Eyeballs Using MALDI Imaging Mass Spectrometry

Oligonucleotide-based therapeutics such as antisense oligonucleotides, small interfering RNAs (siRNAs), decoy and aptamer have been extensively developed. To investigate the pharmacokinetics of oligonucleotide therapeutics, it is common to label a radioisotope in a nucleic acid and visualize it. How...

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Detalles Bibliográficos
Autores principales:	Nakashima, Yuko, Setou, Mitsutoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Mass Spectrometry Society of Japan 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131115/ https://www.ncbi.nlm.nih.gov/pubmed/30214850 http://dx.doi.org/10.5702/massspectrometry.A0070

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