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An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures
Anaplastic meningioma is a rare and aggressive brain tumor characterised by intractable recurrences and dismal outcomes. Here, we present an integrated analysis of the whole genome, transcriptome and methylation profiles of primary and recurrent anaplastic meningioma. A key finding was the delineati...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131140/ https://www.ncbi.nlm.nih.gov/pubmed/30202034 http://dx.doi.org/10.1038/s41598-018-31659-0 |
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| author | Collord, Grace Tarpey, Patrick Kurbatova, Natalja Martincorena, Inigo Moran, Sebastian Castro, Manuel Nagy, Tibor Bignell, Graham Maura, Francesco Young, Matthew D. Berna, Jorge Tubio, Jose M. C. McMurran, Chris E. Young, Adam M. H. Sanders, Mathijs Noorani, Imran Price, Stephen J. Watts, Colin Leipnitz, Elke Kirsch, Matthias Schackert, Gabriele Pearson, Danita Devadass, Abel Ram, Zvi Collins, V. Peter Allinson, Kieren Jenkinson, Michael D. Zakaria, Rasheed Syed, Khaja Hanemann, C. Oliver Dunn, Jemma McDermott, Michael W. Kirollos, Ramez W. Vassiliou, George S. Esteller, Manel Behjati, Sam Brazma, Alvis Santarius, Thomas McDermott, Ultan |
| author_facet | Collord, Grace Tarpey, Patrick Kurbatova, Natalja Martincorena, Inigo Moran, Sebastian Castro, Manuel Nagy, Tibor Bignell, Graham Maura, Francesco Young, Matthew D. Berna, Jorge Tubio, Jose M. C. McMurran, Chris E. Young, Adam M. H. Sanders, Mathijs Noorani, Imran Price, Stephen J. Watts, Colin Leipnitz, Elke Kirsch, Matthias Schackert, Gabriele Pearson, Danita Devadass, Abel Ram, Zvi Collins, V. Peter Allinson, Kieren Jenkinson, Michael D. Zakaria, Rasheed Syed, Khaja Hanemann, C. Oliver Dunn, Jemma McDermott, Michael W. Kirollos, Ramez W. Vassiliou, George S. Esteller, Manel Behjati, Sam Brazma, Alvis Santarius, Thomas McDermott, Ultan |
| author_sort | Collord, Grace |
| collection | PubMed |
| description | Anaplastic meningioma is a rare and aggressive brain tumor characterised by intractable recurrences and dismal outcomes. Here, we present an integrated analysis of the whole genome, transcriptome and methylation profiles of primary and recurrent anaplastic meningioma. A key finding was the delineation of distinct molecular subgroups that were associated with diametrically opposed survival outcomes. Relative to lower grade meningiomas, anaplastic tumors harbored frequent driver mutations in SWI/SNF complex genes, which were confined to the poor prognosis subgroup. Aggressive disease was further characterised by transcriptional evidence of increased PRC2 activity, stemness and epithelial-to-mesenchymal transition. Our analyses discern biologically distinct variants of anaplastic meningioma with prognostic and therapeutic significance. |
| format | Online Article Text |
| id | pubmed-6131140 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-61311402018-09-13 An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures Collord, Grace Tarpey, Patrick Kurbatova, Natalja Martincorena, Inigo Moran, Sebastian Castro, Manuel Nagy, Tibor Bignell, Graham Maura, Francesco Young, Matthew D. Berna, Jorge Tubio, Jose M. C. McMurran, Chris E. Young, Adam M. H. Sanders, Mathijs Noorani, Imran Price, Stephen J. Watts, Colin Leipnitz, Elke Kirsch, Matthias Schackert, Gabriele Pearson, Danita Devadass, Abel Ram, Zvi Collins, V. Peter Allinson, Kieren Jenkinson, Michael D. Zakaria, Rasheed Syed, Khaja Hanemann, C. Oliver Dunn, Jemma McDermott, Michael W. Kirollos, Ramez W. Vassiliou, George S. Esteller, Manel Behjati, Sam Brazma, Alvis Santarius, Thomas McDermott, Ultan Sci Rep Article Anaplastic meningioma is a rare and aggressive brain tumor characterised by intractable recurrences and dismal outcomes. Here, we present an integrated analysis of the whole genome, transcriptome and methylation profiles of primary and recurrent anaplastic meningioma. A key finding was the delineation of distinct molecular subgroups that were associated with diametrically opposed survival outcomes. Relative to lower grade meningiomas, anaplastic tumors harbored frequent driver mutations in SWI/SNF complex genes, which were confined to the poor prognosis subgroup. Aggressive disease was further characterised by transcriptional evidence of increased PRC2 activity, stemness and epithelial-to-mesenchymal transition. Our analyses discern biologically distinct variants of anaplastic meningioma with prognostic and therapeutic significance. Nature Publishing Group UK 2018-09-10 /pmc/articles/PMC6131140/ /pubmed/30202034 http://dx.doi.org/10.1038/s41598-018-31659-0 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Collord, Grace Tarpey, Patrick Kurbatova, Natalja Martincorena, Inigo Moran, Sebastian Castro, Manuel Nagy, Tibor Bignell, Graham Maura, Francesco Young, Matthew D. Berna, Jorge Tubio, Jose M. C. McMurran, Chris E. Young, Adam M. H. Sanders, Mathijs Noorani, Imran Price, Stephen J. Watts, Colin Leipnitz, Elke Kirsch, Matthias Schackert, Gabriele Pearson, Danita Devadass, Abel Ram, Zvi Collins, V. Peter Allinson, Kieren Jenkinson, Michael D. Zakaria, Rasheed Syed, Khaja Hanemann, C. Oliver Dunn, Jemma McDermott, Michael W. Kirollos, Ramez W. Vassiliou, George S. Esteller, Manel Behjati, Sam Brazma, Alvis Santarius, Thomas McDermott, Ultan An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures |
| title | An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures |
| title_full | An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures |
| title_fullStr | An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures |
| title_full_unstemmed | An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures |
| title_short | An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures |
| title_sort | integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131140/ https://www.ncbi.nlm.nih.gov/pubmed/30202034 http://dx.doi.org/10.1038/s41598-018-31659-0 |
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