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Runx2 is required for the proliferation of osteoblast progenitors and induces proliferation by regulating Fgfr2 and Fgfr3
Runx2 and Sp7 are essential transcription factors for osteoblast differentiation. However, the molecular mechanisms responsible for the proliferation of osteoblast progenitors remain unclear. The early onset of Runx2 expression caused limb defects through the Fgfr1–3 regulation by Runx2. To investig...
Autores principales: | Kawane, Tetsuya, Qin, Xin, Jiang, Qing, Miyazaki, Toshihiro, Komori, Hisato, Yoshida, Carolina Andrea, Matsuura-Kawata, Viviane Keiko dos Santos, Sakane, Chiharu, Matsuo, Yuki, Nagai, Kazuhiro, Maeno, Takafumi, Date, Yuki, Nishimura, Riko, Komori, Toshihisa |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131145/ https://www.ncbi.nlm.nih.gov/pubmed/30202094 http://dx.doi.org/10.1038/s41598-018-31853-0 |
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