Microbial metabolite sensor GPR43 controls severity of experimental GVHD

Microbiome-derived metabolites influence intestinal homeostasis and regulate graft-versus-host disease (GVHD), but the molecular mechanisms remain unknown. Here we show the metabolite sensor G-protein-coupled receptor 43 (GPR43) is important for attenuation of gastrointestinal GVHD in multiple clini...

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Detalles Bibliográficos
Autores principales: Fujiwara, Hideaki, Docampo, Melissa D., Riwes, Mary, Peltier, Daniel, Toubai, Tomomi, Henig, Israel, Wu, S. Julia, Kim, Stephanie, Taylor, Austin, Brabbs, Stuart, Liu, Chen, Zajac, Cynthia, Oravecz-Wilson, Katherine, Sun, Yaping, Núñez, Gabriel, Levine, John E., van den Brink, Marcel R.M., Ferrara, James L. M., Reddy, Pavan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131147/
https://www.ncbi.nlm.nih.gov/pubmed/30201970
http://dx.doi.org/10.1038/s41467-018-06048-w

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