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ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes
The HMG-CoA reductase degradation protein 1 (HRD1) has been identified as a key enzyme for endoplasmic reticulum-associated degradation of misfolded proteins, but its organ-specific physiological functions remain largely undefined. Here we show that mice with HRD1 deletion specifically in the liver...
Autores principales: | Wei, Juncheng, Yuan, Yanzhi, Chen, Lu, Xu, Yuanming, Zhang, Yuehui, Wang, Yajun, Yang, Yanjie, Peek, Clara Bien, Diebold, Lauren, Yang, Yi, Gao, Beixue, Jin, Chaozhi, Melo-Cardenas, Johanna, Chandel, Navdeep S., Zhang, Donna D., Pan, Hui, Zhang, Kezhong, Wang, Jian, He, Fuchu, Fang, Deyu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131148/ https://www.ncbi.nlm.nih.gov/pubmed/30201971 http://dx.doi.org/10.1038/s41467-018-06091-7 |
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