Pharmacological c-Jun NH(2)-Terminal Kinase (JNK) Pathway Inhibition Reduces Severity of Spinal Muscular Atrophy Disease in Mice

Spinal muscular atrophy (SMA) is a severe neurodegenerative disorder that occurs in early childhood. The disease is caused by the deletion/mutation of the survival motor neuron 1 (SMN1) gene resulting in progressive skeletal muscle atrophy and paralysis, due to the degeneration of spinal motor neuro...

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Detalles Bibliográficos
Autores principales: Schellino, Roberta, Boido, Marina, Borsello, Tiziana, Vercelli, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131195/
https://www.ncbi.nlm.nih.gov/pubmed/30233310
http://dx.doi.org/10.3389/fnmol.2018.00308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131195/
https://www.ncbi.nlm.nih.gov/pubmed/30233310
http://dx.doi.org/10.3389/fnmol.2018.00308

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