Controlling the regioselectivity and stereospecificity of FAD-dependent polyamine oxidases with the use of amine-attached guide molecules as conformational modulators

Enzymes generally display strict stereospecificity and regioselectivity for their substrates. Here by using FAD-dependent human acetylpolyamine oxidase (APAO), human spermine (Spm) oxidase (SMOX) and yeast polyamine oxidase (Fms1), we demonstrate that these fundamental properties of the enzymes may...

Descripción completa

Detalles Bibliográficos
Autores principales: Keinänen, Tuomo A., Grigorenko, Nikolay, Khomutov, Alex R., Huang, Qingqiu, Uimari, Anne, Alhonen, Leena, Hyvönen, Mervi T., Vepsäläinen, Jouko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131205/
https://www.ncbi.nlm.nih.gov/pubmed/30006473
http://dx.doi.org/10.1042/BSR20180527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131205/
https://www.ncbi.nlm.nih.gov/pubmed/30006473
http://dx.doi.org/10.1042/BSR20180527

Ejemplares similares