Alpl prevents bone ageing sensitivity by specifically regulating senescence and differentiation in mesenchymal stem cells

Mutations in the liver/bone/kidney alkaline phosphatase (Alpl) gene cause hypophosphatasia (HPP) and early-onset bone dysplasia, suggesting that this gene is a key factor in human bone development. However, how and where Alpl acts in bone ageing is largely unknown. Here, we determined that ablation...

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Detalles Bibliográficos
Autores principales: Liu, Wenjia, Zhang, Liqiang, Xuan, Kun, Hu, Chenghu, Liu, Shiyu, Liao, Li, Li, Bei, Jin, Fang, Shi, Songtao, Jin, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131243/
https://www.ncbi.nlm.nih.gov/pubmed/30210899
http://dx.doi.org/10.1038/s41413-018-0029-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131243/
https://www.ncbi.nlm.nih.gov/pubmed/30210899
http://dx.doi.org/10.1038/s41413-018-0029-4

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