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Effects of Toll-like receptor 9 and CpG oligodeoxynucleotides 1826 on sodium taurocholate-induced acute pancreatitis rats
The aim of the present study was to investigate the effects of Toll-like receptor (TLR) 9 and CpG oligodeoxynucleotide (CpG-ODN)1826 on sodium taurocholate-induced acute pancreatitis (AP) rats at different time points. Pathological examination indicated that the severity of pancreatic tissue damage...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131499/ https://www.ncbi.nlm.nih.gov/pubmed/30106134 http://dx.doi.org/10.3892/mmr.2018.9346 |
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author | Sun, Liang Li, Yuanhua Luo, Huayou Wang, Kunhua Li, Li Zeng, Yujian |
author_facet | Sun, Liang Li, Yuanhua Luo, Huayou Wang, Kunhua Li, Li Zeng, Yujian |
author_sort | Sun, Liang |
collection | PubMed |
description | The aim of the present study was to investigate the effects of Toll-like receptor (TLR) 9 and CpG oligodeoxynucleotide (CpG-ODN)1826 on sodium taurocholate-induced acute pancreatitis (AP) rats at different time points. Pathological examination indicated that the severity of pancreatic tissue damage following AP increased with time. Additionally, TLR9 protein levels were upregulated after AP, and were higher at 6 h compared with at 3 h. Subsequently, the TLR9 protein levels were downregulated at 12 h, but remained higher than the control group. In rats subjected to AP, tumor necrosis factor (TNF-α protein expression levels and serum amylase (AMS) in the serum were increased until 12 h. The expression level of TNF-α protein in the AP 12 h group was higher than that in the AP 3 and 6 h groups. In addition, following CpG-ODN1826 administration, the morphology of pancreatic tissue appeared worse compared with that in the AP only groups. Furthermore, CpG-ODN1826 administration induced an increase in TLR9 expression levels compared with the AP alone group at 0, 3, 6 and 12 h. TNF-α in the CpG + AP 12 h group was upregulated compared with that in the CpG + AP 3 and 6 h groups; however, no change was observed between 3 and 6 h. Thus, these data indicate that CpG-ODN1826 aggravates sodium taurocholate-induced pancreas damage in rats. |
format | Online Article Text |
id | pubmed-6131499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-61314992018-09-14 Effects of Toll-like receptor 9 and CpG oligodeoxynucleotides 1826 on sodium taurocholate-induced acute pancreatitis rats Sun, Liang Li, Yuanhua Luo, Huayou Wang, Kunhua Li, Li Zeng, Yujian Mol Med Rep Articles The aim of the present study was to investigate the effects of Toll-like receptor (TLR) 9 and CpG oligodeoxynucleotide (CpG-ODN)1826 on sodium taurocholate-induced acute pancreatitis (AP) rats at different time points. Pathological examination indicated that the severity of pancreatic tissue damage following AP increased with time. Additionally, TLR9 protein levels were upregulated after AP, and were higher at 6 h compared with at 3 h. Subsequently, the TLR9 protein levels were downregulated at 12 h, but remained higher than the control group. In rats subjected to AP, tumor necrosis factor (TNF-α protein expression levels and serum amylase (AMS) in the serum were increased until 12 h. The expression level of TNF-α protein in the AP 12 h group was higher than that in the AP 3 and 6 h groups. In addition, following CpG-ODN1826 administration, the morphology of pancreatic tissue appeared worse compared with that in the AP only groups. Furthermore, CpG-ODN1826 administration induced an increase in TLR9 expression levels compared with the AP alone group at 0, 3, 6 and 12 h. TNF-α in the CpG + AP 12 h group was upregulated compared with that in the CpG + AP 3 and 6 h groups; however, no change was observed between 3 and 6 h. Thus, these data indicate that CpG-ODN1826 aggravates sodium taurocholate-induced pancreas damage in rats. D.A. Spandidos 2018-10 2018-08-03 /pmc/articles/PMC6131499/ /pubmed/30106134 http://dx.doi.org/10.3892/mmr.2018.9346 Text en Copyright: © Sun et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Sun, Liang Li, Yuanhua Luo, Huayou Wang, Kunhua Li, Li Zeng, Yujian Effects of Toll-like receptor 9 and CpG oligodeoxynucleotides 1826 on sodium taurocholate-induced acute pancreatitis rats |
title | Effects of Toll-like receptor 9 and CpG oligodeoxynucleotides 1826 on sodium taurocholate-induced acute pancreatitis rats |
title_full | Effects of Toll-like receptor 9 and CpG oligodeoxynucleotides 1826 on sodium taurocholate-induced acute pancreatitis rats |
title_fullStr | Effects of Toll-like receptor 9 and CpG oligodeoxynucleotides 1826 on sodium taurocholate-induced acute pancreatitis rats |
title_full_unstemmed | Effects of Toll-like receptor 9 and CpG oligodeoxynucleotides 1826 on sodium taurocholate-induced acute pancreatitis rats |
title_short | Effects of Toll-like receptor 9 and CpG oligodeoxynucleotides 1826 on sodium taurocholate-induced acute pancreatitis rats |
title_sort | effects of toll-like receptor 9 and cpg oligodeoxynucleotides 1826 on sodium taurocholate-induced acute pancreatitis rats |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131499/ https://www.ncbi.nlm.nih.gov/pubmed/30106134 http://dx.doi.org/10.3892/mmr.2018.9346 |
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