Cargando…

RXFP1 Receptor Activation by Relaxin-2 Induces Vascular Relaxation in Mice via a Gα(i2)-Protein/PI3Kß/γ/Nitric Oxide-Coupled Pathway

Background: Relaxins are small peptide hormones, which are novel candidate molecules that play important roles in cardiometablic syndrome. Relaxins are structurally related to the insulin hormone superfamily, which provide vasodilatory effects by activation of G-protein-coupled relaxin receptors (RX...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lian, Xiaoming, Beer-Hammer, Sandra, König, Gabriele M., Kostenis, Evi, Nürnberg, Bernd, Gollasch, Maik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131674/ https://www.ncbi.nlm.nih.gov/pubmed/30233409 http://dx.doi.org/10.3389/fphys.2018.01234

Ejemplares similares

Relaxin Receptor RXFP1 and RXFP2 Expression in Ligament, Tendon, and Shoulder Joint Capsule of Rats
por: Kim, Jae Hyung, et al.
Publicado: (2016)

Relaxin family peptide receptors Rxfp1 and Rxfp2: mapping of the mRNA and protein distribution in the reproductive tract of the male rat
por: Filonzi, Marcelo, et al.
Publicado: (2007)

Changes in Knee Laxity and Relaxin Receptor Isoforms Expression (RXFP1/RXFP2) in the Knee throughout Estrous Cycle Phases in Rodents
por: Dehghan, Firouzeh, et al.
Publicado: (2016)

Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3
por: Bathgate, Ross A. D., et al.
Publicado: (2013)

The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1
por: Sethi, Ashish, et al.
Publicado: (2016)

Sex-Steroid Regulation of Relaxin Receptor Isoforms (RXFP1 & RXFP2) Expression in the Patellar Tendon and Lateral Collateral Ligament of Female WKY Rats
por: Dehghan, Firouzeh, et al.
Publicado: (2014)

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1
por: Kocan, Martina, et al.
Publicado: (2017)

The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease
por: Leysen, Hanne, et al.
Publicado: (2022)

Relaxin’ the brain: a case for targeting the nucleus incertus network and relaxin‐3/RXFP3 system in neuropsychiatric disorders
por: Kumar, Jigna Rajesh, et al.
Publicado: (2016)

Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4)
por: Chen, Yan, et al.
Publicado: (2023)

Relaxin 2/RXFP1 Signaling Induces Cell Invasion via the β-Catenin Pathway in Endometrial Cancer
por: Fue, Misaki, et al.
Publicado: (2018)

Multi-Component Mechanism of H2 Relaxin Binding to RXFP1 through NanoBRET Kinetic Analysis
por: Hoare, Bradley L., et al.
Publicado: (2018)

Relaxin-3/RXFP3 networks: an emerging target for the treatment of depression and other neuropsychiatric diseases?
por: Smith, Craig M., et al.
Publicado: (2014)

Relaxin-3 Receptor (RXFP3) Signalling Mediates Stress-Related Alcohol Preference in Mice
por: Walker, Andrew W., et al.
Publicado: (2015)

Relaxin-3/RXFP3 Signaling and Neuroendocrine Function – A Perspective on Extrinsic Hypothalamic Control
por: Ganella, Despina E., et al.
Publicado: (2013)

In search of a small molecule agonist of the relaxin receptor RXFP1 for the treatment of liver fibrosis
por: McBride, Andrew, et al.
Publicado: (2017)

The relaxin family peptide receptor 1 (RXFP1): An emerging player in human health and disease
por: Chen, Ting‐Yun, et al.
Publicado: (2020)

Involvement of the Nucleus Incertus and Relaxin-3/RXFP3 Signaling System in Explicit and Implicit Memory
por: Gil-Miravet, Isis, et al.
Publicado: (2021)

Synthetic short-chain peptide analogues of H1 relaxin lack affinity for the RXFP1 receptor and relaxin-like bioactivity. Clues to a better understanding of relaxin agonist design
por: D'Ercole, Annunziata, et al.
Publicado: (2022)

GABAergic Neurons in the Rat Medial Septal Complex Express Relaxin-3 Receptor (RXFP3) mRNA
por: Albert-Gascó, Hector, et al.
Publicado: (2018)

Investigating the role of the relaxin-3/RXFP3 system in neuropsychiatric disorders and metabolic phenotypes: A candidate gene approach
por: Wong, Win Lee Edwin, et al.
Publicado: (2023)

Synthetic Covalently Linked Dimeric Form of H2 Relaxin Retains Native RXFP1 Activity and Has Improved In Vitro Serum Stability
por: Nair, Vinojini B., et al.
Publicado: (2015)

In a Class of Their Own – RXFP1 and RXFP2 are Unique Members of the LGR Family
por: Petrie, Emma J., et al.
Publicado: (2015)

A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1
por: Hossain, Mohammed Akhter, et al.
Publicado: (2016)

Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, β-arrestin 2, PDE4D3 complex
por: Halls, Michelle L, et al.
Publicado: (2010)

Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons modulate food intake and preference in mice
por: Lewis, Jo E., et al.
Publicado: (2022)

Function, Regulation and Biological Roles of PI3Kγ Variants
por: Nürnberg, Bernd, et al.
Publicado: (2019)

Comparing two versions of the Karolinska Sleepiness Scale (KSS)
por: Miley, Anna Åkerstedt, et al.
Publicado: (2016)

eNOS-NO-induced small blood vessel relaxation requires EHD2-dependent caveolae stabilization
por: Matthaeus, Claudia, et al.
Publicado: (2019)

ODP010 Relaxin Receptor RXFP1 Knockout in Adipose Tissue Progenitor Cells Results in Resistance to High Fat Diet-Induced Weigh Gain
por: Bennett, Robert, et al.
Publicado: (2022)

Translation and Validation of the Knee Society Score - KSS for Brazilian Portuguese
por: Silva, Adriana Lucia Pastore e, et al.
Publicado: (2012)

Nuclear relocation of Kss1 contributes to the specificity of the mating response
por: Pelet, Serge
Publicado: (2017)

C1q/TNF-Related Proteins 1, 6 and 8 Are Involved in Corneal Epithelial Wound Closure by Targeting Relaxin Receptor RXFP1 In Vitro
por: Nicolaus, Hagen Fabian, et al.
Publicado: (2023)

Relaxin receptors and nitric oxide synthases: search for the missing link
por: Nistri, Silvia, et al.
Publicado: (2003)

Kearns Sayre Syndrome (KSS) - A Rare Cause For Cardiac Pacing
por: Gobu, P, et al.
Publicado: (2011)

Familial bilateral cryptorchidism is caused by recessive variants in RXFP2
por: Ayers, Katie, et al.
Publicado: (2019)

Relaxin Signals through a RXFP1-pERK-nNOS-NO-cGMP-Dependent Pathway to Up-Regulate Matrix Metalloproteinases: The Additional Involvement of iNOS
por: Chow, Bryna Suet Man, et al.
Publicado: (2012)

Chimeric RXFP1 and RXFP2 Receptors Highlight the Similar Mechanism of Activation Utilizing Their N-Terminal Low-Density Lipoprotein Class A Modules
por: Bruell, Shoni, et al.
Publicado: (2013)

Relaxin'
Publicado: (1983)

Relaxin
por: DeCherney, Alan H.
Publicado: (1982)

Cannot write session to /tmp/vufind_sessions/sess_6srgm6teefqvafu4gsnbfq9cto