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Enhancer reprogramming in mammalian genomes

BACKGROUND: Transcription factor binding site (TFBS) loss, gain, and reshuffling within the sequence of a regulatory element could alter the function of that regulatory element. Some of the changes will be detrimental to the fitness of the species and will result in gradual removal from a population...

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Detalles Bibliográficos
Autores principales:	Flores, Mario A., Ovcharenko, Ivan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131754/ https://www.ncbi.nlm.nih.gov/pubmed/30200877 http://dx.doi.org/10.1186/s12859-018-2343-7

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