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Comprehensive off-target analysis of dCas9-SAM-mediated HIV reactivation via long noncoding RNA and mRNA profiling

BACKGROUND: CRISPR/CAS9 (epi)genome editing revolutionized the field of gene and cell therapy. Our previous study demonstrated that a rapid and robust reactivation of the HIV latent reservoir by a catalytically-deficient Cas9 (dCas9)-synergistic activation mediator (SAM) via HIV long terminal repeat...

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Detalles Bibliográficos
Autores principales:	Zhang, Yonggang, Arango, Gustavo, Li, Fang, Xiao, Xiao, Putatunda, Raj, Yu, Jun, Yang, Xiao-Feng, Wang, Hong, Watson, Layne T., Zhang, Liqing, Hu, Wenhui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131778/ https://www.ncbi.nlm.nih.gov/pubmed/30200981 http://dx.doi.org/10.1186/s12920-018-0394-2

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