Monosodium urate crystals reduce osteocyte viability and indirectly promote a shift in osteocyte function towards a proinflammatory and proresorptive state

BACKGROUND: Bone erosion is a frequent complication of gout and is strongly associated with tophi, which are lesions comprising inflammatory cells surrounding collections of monosodium urate (MSU) crystals. Osteocytes are important cellular mediators of bone remodeling. The aim of this study was to...

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Detalles Bibliográficos
Autores principales: Chhana, Ashika, Pool, Bregina, Callon, Karen E., Tay, Mei Lin, Musson, David, Naot, Dorit, McCarthy, Geraldine, McGlashan, Susan, Cornish, Jillian, Dalbeth, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131786/
https://www.ncbi.nlm.nih.gov/pubmed/30201038
http://dx.doi.org/10.1186/s13075-018-1704-y

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