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α-Synuclein disrupts the anti-inflammatory role of Drd2 via interfering β-arrestin2-TAB1 interaction in astrocytes

BACKGROUND: α-Synuclein (α-Syn)-induced neuroinflammation plays a crucial role in the pathogenesis of Parkinson’s disease (PD). Dopamine D2 receptor (Drd2) has been regarded as a potential anti-inflammatory target in the therapy of neurodegenerative diseases. However, the effect of astrocytic Drd2 i...

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Detalles Bibliográficos
Autores principales:	Du, Ren-Hong, Zhou, Yan, Xia, Mei-Ling, Lu, Ming, Ding, Jian-Hua, Hu, Gang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131810/ https://www.ncbi.nlm.nih.gov/pubmed/30200997 http://dx.doi.org/10.1186/s12974-018-1302-6

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