Next-generation sequencing analyses of the emergence and maintenance of mutations in CTL epitopes in HIV controllers with differential viremia control

BACKGROUND: Despite the low level of viral replication in HIV controllers (HICs), studies have reported viral mutations related to escape from cytotoxic T-lymphocyte (CTL) response in HIV-1 plasma sequences. Thus, evaluating the dynamics of the emergence of CTL-escape mutants in HICs reservoirs is i...

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Detalles Bibliográficos
Autores principales: Caetano, Diogo Gama, Côrtes, Fernanda Heloise, Bello, Gonzalo, Teixeira, Sylvia Lopes Maia, Hoagland, Brenda, Grinsztejn, Beatriz, Veloso, Valdilea Gonçalves, Guimarães, Monick Lindenmeyer, Morgado, Mariza Gonçalves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131818/
https://www.ncbi.nlm.nih.gov/pubmed/30201008
http://dx.doi.org/10.1186/s12977-018-0444-z

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