Cargando…

Changing expression profiles of long non-coding RNAs, mRNAs and circular RNAs in ethylene glycol-induced kidney calculi rats

BACKGROUND: To explore long non-coding RNA (lncRNA), mRNA and circular RNA (circRNA) expression profiles and their biological functions in the pathogenesis of kidney stones in ethylene glycol-induced urolithiasis rats. RESULTS: The expression of 1440 lncRNAs, 2455 mRNAs and 145 circRNAs was altered...

Descripción completa

Detalles Bibliográficos
Autores principales: Cao, Yanan, Gao, Xiaowei, Yang, Yue, Ye, Zhi, Wang, E., Dong, Zhitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131827/
https://www.ncbi.nlm.nih.gov/pubmed/30200873
http://dx.doi.org/10.1186/s12864-018-5052-8
_version_ 1783354203338440704
author Cao, Yanan
Gao, Xiaowei
Yang, Yue
Ye, Zhi
Wang, E.
Dong, Zhitao
author_facet Cao, Yanan
Gao, Xiaowei
Yang, Yue
Ye, Zhi
Wang, E.
Dong, Zhitao
author_sort Cao, Yanan
collection PubMed
description BACKGROUND: To explore long non-coding RNA (lncRNA), mRNA and circular RNA (circRNA) expression profiles and their biological functions in the pathogenesis of kidney stones in ethylene glycol-induced urolithiasis rats. RESULTS: The expression of 1440 lncRNAs, 2455 mRNAs and 145 circRNAs was altered in the kidneys of urolithiasis rats. GO and KEGG biological pathway analysis were performed to predict the functions of differentially expressed lncRNAs, circRNAs and co-expressed potential targeting genes. Co-expression networks of lncRNA-mRNA and circRNA-miRNA were constructed based on correlation analysis between differentially expressed RNAs. mRNAs coexpressed with lncRNAs were involved in many kidney diseases, e.g., Ephb6 was associated with the reabsorption ability of the kidney. Arl5b was associated with the dynamic changes in the podocyte foot process in podocyte injury. miRNAs co-expressed with circRNAs, such as rno-miR-138-5p and rno-miR-672-5p, have been proven to be functional in hypercalciuria urolithiasis. CONCLUSION: The expression profile provided a systematic perspective on the potential functions of lncRNAs and circRNAs in the pathogenesis of kidney stones. Differentially expressed lncRNAs and circRNAs might serve as treatment targets for kidney stones. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12864-018-5052-8) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-6131827
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-61318272018-09-13 Changing expression profiles of long non-coding RNAs, mRNAs and circular RNAs in ethylene glycol-induced kidney calculi rats Cao, Yanan Gao, Xiaowei Yang, Yue Ye, Zhi Wang, E. Dong, Zhitao BMC Genomics Research Article BACKGROUND: To explore long non-coding RNA (lncRNA), mRNA and circular RNA (circRNA) expression profiles and their biological functions in the pathogenesis of kidney stones in ethylene glycol-induced urolithiasis rats. RESULTS: The expression of 1440 lncRNAs, 2455 mRNAs and 145 circRNAs was altered in the kidneys of urolithiasis rats. GO and KEGG biological pathway analysis were performed to predict the functions of differentially expressed lncRNAs, circRNAs and co-expressed potential targeting genes. Co-expression networks of lncRNA-mRNA and circRNA-miRNA were constructed based on correlation analysis between differentially expressed RNAs. mRNAs coexpressed with lncRNAs were involved in many kidney diseases, e.g., Ephb6 was associated with the reabsorption ability of the kidney. Arl5b was associated with the dynamic changes in the podocyte foot process in podocyte injury. miRNAs co-expressed with circRNAs, such as rno-miR-138-5p and rno-miR-672-5p, have been proven to be functional in hypercalciuria urolithiasis. CONCLUSION: The expression profile provided a systematic perspective on the potential functions of lncRNAs and circRNAs in the pathogenesis of kidney stones. Differentially expressed lncRNAs and circRNAs might serve as treatment targets for kidney stones. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12864-018-5052-8) contains supplementary material, which is available to authorized users. BioMed Central 2018-09-10 /pmc/articles/PMC6131827/ /pubmed/30200873 http://dx.doi.org/10.1186/s12864-018-5052-8 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Cao, Yanan
Gao, Xiaowei
Yang, Yue
Ye, Zhi
Wang, E.
Dong, Zhitao
Changing expression profiles of long non-coding RNAs, mRNAs and circular RNAs in ethylene glycol-induced kidney calculi rats
title Changing expression profiles of long non-coding RNAs, mRNAs and circular RNAs in ethylene glycol-induced kidney calculi rats
title_full Changing expression profiles of long non-coding RNAs, mRNAs and circular RNAs in ethylene glycol-induced kidney calculi rats
title_fullStr Changing expression profiles of long non-coding RNAs, mRNAs and circular RNAs in ethylene glycol-induced kidney calculi rats
title_full_unstemmed Changing expression profiles of long non-coding RNAs, mRNAs and circular RNAs in ethylene glycol-induced kidney calculi rats
title_short Changing expression profiles of long non-coding RNAs, mRNAs and circular RNAs in ethylene glycol-induced kidney calculi rats
title_sort changing expression profiles of long non-coding rnas, mrnas and circular rnas in ethylene glycol-induced kidney calculi rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131827/
https://www.ncbi.nlm.nih.gov/pubmed/30200873
http://dx.doi.org/10.1186/s12864-018-5052-8
work_keys_str_mv AT caoyanan changingexpressionprofilesoflongnoncodingrnasmrnasandcircularrnasinethyleneglycolinducedkidneycalculirats
AT gaoxiaowei changingexpressionprofilesoflongnoncodingrnasmrnasandcircularrnasinethyleneglycolinducedkidneycalculirats
AT yangyue changingexpressionprofilesoflongnoncodingrnasmrnasandcircularrnasinethyleneglycolinducedkidneycalculirats
AT yezhi changingexpressionprofilesoflongnoncodingrnasmrnasandcircularrnasinethyleneglycolinducedkidneycalculirats
AT wange changingexpressionprofilesoflongnoncodingrnasmrnasandcircularrnasinethyleneglycolinducedkidneycalculirats
AT dongzhitao changingexpressionprofilesoflongnoncodingrnasmrnasandcircularrnasinethyleneglycolinducedkidneycalculirats