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A novel synthetic trivalent single chain variable fragment (tri-scFv) construction platform based on the SpyTag/SpyCatcher protein ligase system
BACKGROUND: Advances in antibody engineering provide strategies to construct recombinant antibody-like molecules with modified pharmacokinetic properties. Multermerization is one strategy that has been used to produce antibody-like molecules with two or more antigen binding sites. Multimerization en...
Autores principales: | Alam, Md. Kausar, Brabant, Michelle, Viswas, Raja Solomon, Barreto, Kris, Fonge, Humphrey, Ronald Geyer, C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131909/ https://www.ncbi.nlm.nih.gov/pubmed/30200951 http://dx.doi.org/10.1186/s12896-018-0466-6 |
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