Cargando…

Antioxidative CXXC Peptide Motif From Mesencephalic Astrocyte-Derived Neurotrophic Factor Antagonizes Programmed Cell Death

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a potent survival-promoting protein with neurorestorative effect for neurodegenerative diseases. Its mechanism of action, albeit poorly known, depends strongly on the CXXC motif (CKGC). Here we studied the survival-promoting properties of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Božok, Valentina, Yu, Li-ying, Palgi, Jaan, Arumäe, Urmas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132022/ https://www.ncbi.nlm.nih.gov/pubmed/30234112 http://dx.doi.org/10.3389/fcell.2018.00106

Ejemplares similares

Role of two sequence motifs of mesencephalic astrocyte-derived neurotrophic factor in its survival-promoting activity
por: Mätlik, K, et al.
Publicado: (2015)

Emerging Roles for Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) in Pancreatic Beta Cells and Diabetes
por: Danilova, Tatiana, et al.
Publicado: (2018)

Microarray Analysis Reveals Increased Transcriptional Repression and Reduced Metabolic Activity but Not Major Changes in the Core Apoptotic Machinery during Maturation of Sympathetic Neurons
por: Raba, Mikk, et al.
Publicado: (2016)

Photoreceptor Protection by Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF)
por: Lu, Jianmin, et al.
Publicado: (2018)

Mesencephalic Astrocyte-Derived Neurotrophic Factor Regulates Morphology of Pigment-Dispersing Factor-Positive Clock Neurons and Circadian Neuronal Plasticity in Drosophila melanogaster
por: Krzeptowski, Wojciech, et al.
Publicado: (2021)

Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Upregulated with Therapeutic Fasting in Humans and Diet Fat Withdrawal in Obese Mice
por: Galli, Emilia, et al.
Publicado: (2019)

Expression and Distribution of Mesencephalic Astrocyte-Derived Neurotrophic Factor in the Retina and Optic Nerve
por: Gao, Feng-Juan, et al.
Publicado: (2017)

Role of Mesencephalic Astrocyte-Derived Neurotrophic Factor in Alcohol-Induced Liver Injury
por: Chhetri, Goma, et al.
Publicado: (2020)

Increased Serum Levels of Mesencephalic Astrocyte-Derived Neurotrophic Factor in Subjects With Parkinson’s Disease
por: Galli, Emilia, et al.
Publicado: (2019)

Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF): An Emerging Therapeutic Target for Neurodegenerative Disorders
por: Sivakumar, Bhadrapriya, et al.
Publicado: (2023)

Increased circulating concentrations of mesencephalic astrocyte-derived neurotrophic factor in children with type 1 diabetes
por: Galli, Emilia, et al.
Publicado: (2016)

Transcriptional regulation of mouse mesencephalic astrocyte-derived neurotrophic factor in Neuro2a cells
por: Oh-Hashi, Kentaro, et al.
Publicado: (2013)

Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Is Highly Expressed in Mouse Tissues With Metabolic Function
por: Danilova, Tatiana, et al.
Publicado: (2019)

Neuroprotective and reparative effects of endoplasmic reticulum luminal proteins – mesencephalic astrocyte-derived neurotrophic factor and cerebral dopamine neurotrophic factor
por: Albert, Katrina, et al.
Publicado: (2019)

Upregulation of mesencephalic astrocyte-derived neurotrophic factor in glial cells is associated with ischemia-induced glial activation
por: Shen, Yujun, et al.
Publicado: (2012)

Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Involved in Inflammation by Negatively Regulating the NF-κB Pathway
por: Chen, Lijian, et al.
Publicado: (2015)

Identification of Mesencephalic Astrocyte-Derived Neurotrophic Factor as a Novel Neuroprotective Factor for Retinal Ganglion Cells
por: Gao, Feng-Juan, et al.
Publicado: (2017)

Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Elevates Stimulus-Evoked Release of Dopamine in Freely-Moving Rats
por: Renko, Juho-Matti, et al.
Publicado: (2018)

The CXXC Motifs Are Essential for the Function of BosR in Borrelia burgdorferi
por: Mason, Charlotte, et al.
Publicado: (2019)

An evolutionary perspective on the role of mesencephalic astrocyte-derived neurotrophic factor (MANF): At the crossroads of poriferan innate immune and apoptotic pathways
por: Sereno, Dayane, et al.
Publicado: (2017)

Mesencephalic astrocyte-derived neurotrophic factor ameliorates steatosis in HepG2 cells by regulating hepatic lipid metabolism
por: He, Miao, et al.
Publicado: (2020)

Prognostic potential of serum mesencephalic astrocyte-derived neurotrophic factor in acute intracerebral hemorrhage: a prospective observational study
por: Zhang, Cheng-Liang, et al.
Publicado: (2023)

Mesencephalic astrocyte-derived neurotrophic factor reduces cell apoptosis via upregulating HSP70 in SHSY-5Y cells
por: Sun, Hui, et al.
Publicado: (2017)

Mesencephalic astrocyte-derived neurotrophic factor is secreted from interferon-γ–activated tumor cells through ER calcium depletion
por: Peled, Michael, et al.
Publicado: (2021)

The Potential Protective Effect of Mesencephalic Astrocyte-Derived Neurotrophic Factor on Post-Operative Delirium via Inhibiting Inflammation and Microglia Activation
por: Liu, Jing, et al.
Publicado: (2021)

Mesencephalic Astrocyte-Derived Neurotrophic Factor, a Prognostic Factor of Cholangiocarcinoma, Affects Sorafenib Sensitivity of Cholangiocarcinoma Cells by Deteriorating ER Stress
por: He, Jingyi, et al.
Publicado: (2020)

Mesencephalic astrocyte-derived neurotrophic factor reprograms macrophages to ameliorate acetaminophen-induced acute liver injury via p38 MAPK pathway
por: Hou, Xin, et al.
Publicado: (2022)

Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra
por: Mätlik, Kert, et al.
Publicado: (2017)

Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects against Aβ toxicity via attenuating Aβ-induced endoplasmic reticulum stress
por: Xu, Shengchun, et al.
Publicado: (2019)

Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Regulates Neurite Outgrowth Through the Activation of Akt/mTOR and Erk/mTOR Signaling Pathways
por: Wen, Wen, et al.
Publicado: (2020)

Cell differentiation: reciprocal regulation of Apaf-1 and the inhibitor of apoptosis proteins
por: Lindholm, Dan, et al.
Publicado: (2004)

A Conserved CXXC Motif in CD3ε Is Critical for T Cell Development and TCR Signaling
por: Wang, Yibing, et al.
Publicado: (2009)

The BCAT1 CXXC Motif Provides Protection against ROS in Acute Myeloid Leukaemia Cells
por: Hillier, James, et al.
Publicado: (2022)

The Pressor Response to Concurrent Stimulation of the Mesencephalic Locomotor Region and Peripheral Sensory Afferents Is Attenuated in Normotensive but Not Hypertensive Rats
por: Liang, Nan, et al.
Publicado: (2019)

Mesencephalic astrocyte-derived neurotropic factor is an important factor in chondrocyte ER homeostasis
por: Bell, P. A., et al.
Publicado: (2018)

Correlation of Significantly Decreased Serum Circulating Mesencephalic Astrocyte-Derived Neurotrophic Factor Level With an Increased Risk of Future Cardiovascular Disease in Adult Patients With Growth Hormone Deficiency
por: Ren, Ziyu, et al.
Publicado: (2021)

Functional Organization of Sequence Motifs in Diverse Transit Peptides of Chloroplast Proteins
por: Jeong, Jinseung, et al.
Publicado: (2021)

Constipation Caused by Anti-calcitonin Gene-Related Peptide Migraine Therapeutics Explained by Antagonism of Calcitonin Gene-Related Peptide’s Motor-Stimulating and Prosecretory Function in the Intestine
por: Holzer, Peter, et al.
Publicado: (2022)

Commentary: Constipation caused by anti-calcitonin gene-related peptide migraine therapeutics explained by antagonism of calcitonin gene-related peptide’s motor-stimulating and prosecretory function in the intestine
por: Mackenzie, Kimberly D., et al.
Publicado: (2022)

Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Protects Against Neuronal Apoptosis via Activation of Akt/MDM2/p53 Signaling Pathway in a Rat Model of Intracerebral Hemorrhage
por: Xu, Weilin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_7f0kne9b04eiaffckcabgln6bn