Cargando…

PKCι and YAP1 are crucial in promoting pancreatic tumorigenesis

Pancreatic ductal adenocarcinoma (PDAC) is a fatal malignant disease with 5-year survival rate of less than 6%. Activating mutations of Kras (mu-Kras) are often detected in most of PDAC patients. Although it has been known that oncogenic Kras is the driver of pancreatic cancer initiation and develop...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Peipei, Wei, Dapeng, Zhang, Hongmei, Chen, Jiao, Zhang, Dingding, Ganapathy, Suthakar, Isakson, Pauline, Chen, Changyan, Zhu, Tongbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132349/ https://www.ncbi.nlm.nih.gov/pubmed/30214681 http://dx.doi.org/10.18632/oncotarget.25127

Ejemplares similares

PKCι regulates nuclear YAP1 localization and ovarian cancer tumorigenesis
por: Wang, Yin, et al.
Publicado: (2016)

Nicotine exposure potentiates lung tumorigenesis by perturbing cellular surveillance
por: Zhang, Qiang, et al.
Publicado: (2020)

PKC is an indispensable factor in promoting environmental toxin chromium-mediated transformation and drug resistance
por: Ganapathy, Suthakar, et al.
Publicado: (2022)

Coordination of glioblastoma cell motility by PKCι
por: Baldwin, R Mitchell, et al.
Publicado: (2010)

Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors
por: Ratnayake, Wishrawana S., et al.
Publicado: (2018)

Suppression of PKC causes oncogenic stress for triggering apoptosis in cancer cells
por: Ganapathy, Suthakar, et al.
Publicado: (2017)

aPKCι promotes gallbladder cancer tumorigenesis and gemcitabine resistance by competing with Nrf2 for binding to Keap1
por: Tian, Li, et al.
Publicado: (2019)

Correction: Suppression of PKC causes oncogenic stress for triggering apoptosis in cancer cells
por: Ganapathy, Suthakar, et al.
Publicado: (2023)

PKCι depletion initiates mitotic slippage-induced senescence in glioblastoma
por: Restall, Ian J, et al.
Publicado: (2015)

Investigating pathogenic SNP of PKCι in HCV-induced hepatocellular carcinoma
por: Khan, Naila, et al.
Publicado: (2023)

The aPKCι blocking agent ATM negatively regulates EMT and invasion of hepatocellular carcinoma
por: Ma, C Q, et al.
Publicado: (2014)

Lack of an association between the aPKCλ/ι expression in prostate cancer and the patient outcomes
por: Yokomizo, Yumiko, et al.
Publicado: (2017)

PKCλ/ι signaling—a common node for normal cellular development and breast oncogenesis
por: Paul, Arindam, et al.
Publicado: (2015)

Clinical significance of atypical protein kinase C (PKCι and PKCζ) and its relationship with yes-associated protein in lung adenocarcinoma
por: Kim, Kyung-Hee, et al.
Publicado: (2019)

The Rho family GEF FARP2 is activated by aPKCι to control tight junction formation and polarity
por: Elbediwy, Ahmed, et al.
Publicado: (2019)

Ect2 links the PKCι-Par6α Complex to Rac1 Activation and Cellular Transformation
por: Justilien, Verline, et al.
Publicado: (2009)

PKCι interacts with Rab14 and modulates epithelial barrier function through regulation of claudin-2 levels
por: Lu, Ruifeng, et al.
Publicado: (2015)

Chronic low dose arsenic exposure preferentially perturbs mitotic phase of the cell cycle
por: Ganapathy, Suthakar, et al.
Publicado: (2019)

Downregulation of ASPP2 promotes gallbladder cancer metastasis and macrophage recruitment via aPKC-ι/GLI1 pathway
por: Tian, Li, et al.
Publicado: (2018)

Conditional knockout of polarity complex (atypical) PKCι reveals an anti-inflammatory function mediated by NF-κB
por: Forteza, Radia, et al.
Publicado: (2016)

Targeting PKCι-PAK1 signaling pathways in EGFR and KRAS mutant adenocarcinoma and lung squamous cell carcinoma
por: Ito, Masaoki, et al.
Publicado: (2019)

Deficiency of PKCλ/ι alleviates the liver pathologic impairment of Schistosoma japonicum infection by thwarting Th2 response
por: Mei, Congjin, et al.
Publicado: (2022)

Atypical protein kinase C iota (PKCλ/ι) ensures mammalian development by establishing the maternal–fetal exchange interface
por: Bhattacharya, Bhaswati, et al.
Publicado: (2020)

Control of atypical PKCι membrane dissociation by tyrosine phosphorylation within a PB1-C1 interdomain interface
por: Cobbaut, Mathias, et al.
Publicado: (2023)

The ΙgΕ-epitome viewed through the eyes of human monoclonal ΙgΕ
por: Levin, Mattias, et al.
Publicado: (2014)

A lethal synergy induced by phellinus linteus and camptothecin11 in colon cancer cells
por: Yu, Tianqi, et al.
Publicado: (2018)

Targeting Bcl-2 stability to sensitize cells harboring oncogenic ras
por: Peng, Bo, et al.
Publicado: (2015)

PKC Regulates YAP Expression through Alternative Splicing of YAP 3′UTR Pre-mRNA by hnRNP F
por: Chu, Wing-Keung, et al.
Publicado: (2021)

14-3-3ζ and aPKC-ι synergistically facilitate epithelial-mesenchymal transition of cholangiocarcinoma via GSK-3β/snail signaling pathway
por: Yang, Yan, et al.
Publicado: (2016)

Ral A, via activating the mitotic checkpoint, sensitizes cells lacking a functional Nf1 to apoptosis in the absence of protein kinase C
por: Ganapathy, Suthakar, et al.
Publicado: (2016)

Transcription co-activator P300 activates Elk1-aPKC-ι signaling mediated epithelial-to-mesenchymal transition and malignancy in hepatocellular carcinoma
por: Ma, Chaoqun, et al.
Publicado: (2020)

Effects of Atypical Protein Kinase C Inhibitor (DNDA) on Lung Cancer Proliferation and Migration by PKC-ι/FAK Ubiquitination Through the Cbl-b Pathway
por: BommaReddy, Raja Reddy, et al.
Publicado: (2020)

YAP promotes tumorigenesis and cisplatin resistance in neuroblastoma
por: Yang, Chao, et al.
Publicado: (2017)

Fbxw7 Deletion Accelerates Kras(G12D)-Driven Pancreatic Tumorigenesis via Yap Accumulation()()()
por: Zhang, Qiang, et al.
Publicado: (2016)

Posttranslational Regulation of Human DNA Polymerase ι
por: McIntyre, Justyna, et al.
Publicado: (2015)

Mechanotransduction and Cytoskeleton Remodeling Shaping YAP1 in Gastric Tumorigenesis
por: Zhang, Jinglin, et al.
Publicado: (2019)

Correction: YAP promotes tumorigenesis and cisplatin resistance in neuroblastoma
por: Yang, Chao, et al.
Publicado: (2022)

Active YAP promotes pancreatic cancer cell motility, invasion and tumorigenesis in a mitotic phosphorylation-dependent manner through LPAR3
por: Yang, Shuping, et al.
Publicado: (2015)

LncRNA PWAR6 regulates proliferation and migration by epigenetically silencing YAP1 in tumorigenesis of pancreatic ductal adenocarcinoma
por: Huang, Shanshan, et al.
Publicado: (2021)

C-MYC and BCL-2 mediate YAP-regulated tumorigenesis in OSCC
por: Chen, Xiyan, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_3r5vt45mj589ke8u5vb17qjb0q