Beyond the 3′UTR binding–microRNA-induced protein truncation via DNA binding

Here, we present a miR mechanism which is active in the nucleus and is essential for the production of intron included, C-terminal truncated and biologically active proteins, like e.g. Vim3. We exemplified this mechanism by miRs, miR-15a and miR-498, which are overexpressed in clear cell renal carci...

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Detalles Bibliográficos
Autores principales: von Brandenstein, Melanie, Bernhart, Stephan H., Pansky, Andreas, Richter, Claudia, Kohl, Tobias, Deckert, Martina, Heidenreich, Axel, Stadler, Peter F., Montesinos-Rongen, Manuel, Fries, Jochen W.U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132356/
https://www.ncbi.nlm.nih.gov/pubmed/30214689
http://dx.doi.org/10.18632/oncotarget.26023

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