Vitamin C promotes decitabine or azacytidine induced DNA hydroxymethylation and subsequent reactivation of the epigenetically silenced tumour suppressor CDKN1A in colon cancer cells

Epigenetic silencing of tumour suppressor genes is a key hallmark of colorectal carcinogenesis. Despite this, the therapeutic potential of epigenetic agents capable of reactivating these silenced genes remains relatively unexplored. Evidence has shown the dietary antioxidant vitamin C (ascorbate) ac...

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Detalles Bibliográficos
Autores principales: Gerecke, Christian, Schumacher, Fabian, Edlich, Alexander, Wetzel, Alexandra, Yealland, Guy, Neubert, Lena Katharina, Scholtka, Bettina, Homann, Thomas, Kleuser, Burkhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132357/
https://www.ncbi.nlm.nih.gov/pubmed/30214687
http://dx.doi.org/10.18632/oncotarget.25999

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